 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 12145/12927 (94%)
Visitors : 848449
Online Users : 1059
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/16195
|
| Title: | MicroRNA dynamics in irisin-mediated signaling pathways within adipose tissue |
| Authors: | Ho, MY;Chiu, KP;Tsai, ML;Yeh, JK;Huang, YC;Li, YR;Wang, HD;Hsieh, IC;Wen, MS;Wang, CY |
| Contributors: | Institute of Cellular and Systems Medicine |
| Abstract: | The regulation of adipose tissue metabolism by irisin involves modulating gene expressions related to energy metabolism and insulin sensitivity via miRNA-mediated signaling pathways within adipose tissue. Understanding the molecular mechanisms behind the role of irisin is vital for addressing obesity and related metabolic complications. In this study, we undertook an extensive miRNA transcriptomic approach to identify differentially expressed miRNAs following irisin exposure in adipocytes and murine white adipose tissue. Our findings spotlighted two miRNAs, miRNA-758 and miRNA-668, as being influenced by irisin. To understand the impact of the modulations of these miRNAs by irisin, we performed a signaling pathway and network analysis. After irisin exposure, both, miRNA-758 and miRNA-668, emerged as key regulators in leptin and CDK5 signaling pathways. Leptin, a hormone originating from adipose tissue, is primarily produced by adipocytes, and its effects are known to be mediated by CDK5. In essence, this study identifies pivotal genes and miRNAs in irisin-driven mechanisms in adipose tissue, offering valuable insights for crafting novel therapeutic strategies for metabolic and associated disorders. |
| Date: | 2024-09-30 |
| Relation: | Journal of Biosciences. 2024 Sep 30;49(4):Article number 89. |
| Link to: | http://dx.doi.org/10.1007/s12038-024-00475-2 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-5991&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001322691800001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85205680469 |
| Appears in Collections: | [王朝永] 期刊論文
|
Files in This Item:
| File |
Size | Format | |
|---|
| ISI001322691800001.pdf | 1580Kb | Adobe PDF | 6 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
