國家衛生研究院 NHRI:Item 3990099045/16142
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    題名: Rapid green analytical methodology for simultaneous monitoring of nitrosamines and semi-volatile organic compounds in water and human urine samples
    作者: Hu, ST;Shashikumar, U;Gurrani, S;Tseng, YT;Prakasham, K;Huang, CT;Krishnan, A;Wang, CE;Huang, PC;Ponnusamy, VK
    貢獻者: National Institute of Environmental Health Sciences
    摘要: Nitrosamines and semi-volatile organic compounds (SVOCs) are carcinogenic contaminants in water and biological matrices. Conventional analytical methods often struggle to detect trace concentrations due to poor extraction efficacies. This study presents a novel, low-cost, in-syringe-assisted fast extraction cum cleanup technique coupled with GC-FID for monitoring four nitrosamines and two SVOCs in drinking water and human urine samples to measure the contamination and exposure levels. This extraction protocol combines a novel green in-syringe liquid-liquid extraction step using dimethyl carbonate as the green extraction solvent, coupled with a semi-automated solid-phase extraction cleanup process. Then, the final extractant is analyzed using gas chromatography-flame ionization detection (GC-FID) for monitoring. The method demonstrated excellent linearity (R(2) > 0.998) between 1.5 and 500 ng mL⁻(1) for all six target compounds. Detection limits ranged from 1.0 to 2.0 ng mL⁻(1). Extraction recoveries were between 87 and 105% for both urine samples and water samples. Intra-day and inter-day precision were below 9% RSD. The blue applicability grade index evaluation scored 70.0, indicating good practical applicability. The developed analytical protocol offers a sensitive, accurate, low-cost, rapid, and environmentally friendly method for simultaneously quantifying multiple nitrosamines and SVOCs in environmental and human samples. Its performance characteristics and sustainability metrics suggest the potential for broad application in monitoring and exposure studies.
    日期: 2024-09-24
    關聯: Environmental Geochemistry and Health. 2024 Sep 24;46(11):Article number 433.
    Link to: http://dx.doi.org/10.1007/s10653-024-02207-9
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0269-4042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001319917900025
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85204873728
    顯示於類別:[黃柏菁] 期刊論文

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