國家衛生研究院 NHRI:Item 3990099045/16136
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16136


    Title: The mitochondrial stress signaling tunes immunity from a view of systemic tumor microenvironment and ecosystem
    Authors: Kuo, CL;Lin, YC;Lo, YK;Lu, YZ;Babuharisankar, AP;Lien, HW;Chou, HY;Lee, AY
    Contributors: National Institute of Cancer Research
    Abstract: Mitochondria play important roles in cell fate, calcium signaling, mitophagy, and the signaling through reactive oxygen species (ROS). Recently, mitochondria are considered as a signaling organelle in the cell and communicate with other organelles to constitute the mitochondrial information processing system (MIPS) that transduce input-to-output biological information. The success in immunotherapy, a concept of systemic therapy, has been proved to be dependent on paracrine interactions within the tumor microenvironment (TME) and distant organs including microbiota and immune components. We will adopt a broader view from the concept of TME to tumor micro- and macroenvironment (TM (2) E) or tumor-organ ecosystem (TOE). In this review, we will discuss the role of mitochondrial signaling by mitochondrial ROS, calcium flux, metabolites, mtDNA, vesicle transportation, and mitochondria-derived peptide in the TME and TOE, in particular immune regulation and effective cancer immunotherapy.
    Date: 2024-09-20
    Relation: iScience. 2024 Sep 20;27(9):Article number 110710.
    Link to: http://dx.doi.org/10.1016/j.isci.2024.110710
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2589-0042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001301399900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85207357248
    Appears in Collections:[Alan Yueh-Luen Lee] Periodical Articles

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