國家衛生研究院 NHRI:Item 3990099045/16122
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16122


    Title: Motion sensing by a highly sensitive nanogold strain sensor in a biomimetic 3D environment
    Authors: Wu, SD;Weller, H;Vossmeyer, T;Hsu, SH
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Recent advancements in flexible electronics have highlighted their potential in biomedical applications, primarily due to their human-friendly nature. This study introduces a new flexible electronic system designed for motion sensing in a biomimetic three-dimensional (3D) environment. The system features a self-healing gel matrix (chitosan-based hydrogel) that effectively mimics the dynamics of the extracellular matrix (ECM), and is integrated with a highly sensitive thin-film resistive strain sensor, which is fabricated by incorporating a cross-linked gold nanoparticle (GNP) thin film as the active conductive layer onto a biocompatible microphase-separated polyurethane (PU) substrate through a clean, rapid, and high-precision contact printing method. The GNP-PU strain sensor demonstrates high sensitivity (a gauge factor of similar to 50), good stability, and waterproofing properties. The feasibility of detecting small motion was evaluated by sensing the beating of human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte spheroids embedded in the gel matrix. The integration of these components exemplifies a proof-of-concept for using flexible electronics comprising self-healing hydrogel and thin-film nanogold in cardiac sensing and offers promising insights into the development of next-generation biomimetic flexible electronic devices.
    Date: 2024-10
    Relation: ACS Applied Materials and Interfaces. 2024 Oct 23;16(42):56599-56610.
    Link to: http://dx.doi.org/10.1021/acsami.4c08105
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1944-8244&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001310129200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85204919518
    Appears in Collections:[Shan-Hui Hsu] Periodical Articles

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