國家衛生研究院 NHRI:Item 3990099045/16121

NHRI > National Center for Geriatrics and Welfare Research > Shi-Heng Wang > Periodical Articles > Item 3990099045/16121

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16121

Title:	Associations of polygenic risk for depression, traditional Chinese medicine constitution, and depression: A population-based study in Taiwan
Authors:	Hsu, YC;Su, MH;Chen, CY;Lin, YF;Wang, SH
Contributors:	National Center for Geriatrics and Welfare Research;Institute of Population Health Sciences
Abstract:	To comprehensively investigate the risk factors associated with depression, traditional Chinese medicine constitution (TCMC) has been found to be related to depression. However, the underlying mechanism remains unclear. This study examined the association between the concept of unbalanced TCMCs and major depressive disorder (MDD), investigated the overlapping polygenic risks between unbalanced TCMC and MDD, and performed a mediation test to establish potential pathways. In total, 11,030 individuals were recruited from the Taiwan Biobank, and the polygenic risk score (PRS) for MDD for each participant was calculated using the data from the Psychiatric Genomics Consortium. Unbalanced TCMC were classified as yang-deficiency, yin-deficiency, and stasis. The MDD PRS was associated with yang-deficiency odds ratio [OR] per standard deviation increase in standardized (PRS = 1.07, p = 0.0080), yin-deficiency (OR = 1.07, p = 0.0030), and stasis constitution (OR = 1.06, p = 0.0331). Yang-deficiency (OR = 2.07, p < 0.0001) and stasis constitutions (OR = 1.65, p = 0.0015) were associated with an increased risk of MDD. A higher number of unbalanced constitutions was associated with MDD (p < 0.0001). The effect of MDD PRS on MDD was partly mediated by yang-deficiency (10.21%) and stasis (8.41%) constitutions. This study provides evidence for the shared polygenic risk mechanism underlying depression and TCMC and the potential mediating role of TCMC in the polygenic liability for MDD.
Date:	2024-09-10
Relation:	American Journal of Medical Genetics Part B-Neuropsychiatric Genetics. 2024 Sep;Article in Press.
Link to:	http://dx.doi.org/10.1002/ajmg.b.33007
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1552-4841&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001309836100001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85203500654
Appears in Collections:	[Shi-Heng Wang] Periodical Articles [Yen-Feng Lin] Periodical Articles

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