國家衛生研究院 NHRI:Item 3990099045/16118
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16118


    Title: Oxygen-binding sites of enriched gold nanoclusters for capturing mitochondrial reverse electrons
    Authors: Liao, FH;Chen, SP;Yao, CN;Wu, TH;Liu, MT;Hsu, CS;Chen, HM;Lin, SY
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: Reverse electron transfer (RET), an abnormal backward flow of electrons from complexes III/IV to II/I of mitochondria, causes the overproduction of a reduced-type CoQ to boost downstream production of mitochondrial superoxide anions that leads to ischemia-reperfusion injury (IRI) to organs. Herein, we studied low-coordinated gold nanoclusters (AuNCs) with abundant oxygen-binding sites to form an electron-demanding trapper that allowed rapid capture of electrons to compensate for the CoQ/CoQH(2) imbalance during RET. The AuNCs were composed of only eight gold atoms that formed a Cs-symmetrical configuration with all gold atoms exposed on the edge site. The geometry and atomic configuration enhance oxygen intercalation to attain a d-band electron deficiency in frontier orbitals, forming an unusually high oxidation state for rapid mitochondrial reverse electron capture under a transient imbalance of CoQ/CoQH(2) redox cycles. Using hepatic IRI cells/animals, we corroborated that the CoQ-like AuNCs prevent inflammation and liver damage from IRI via recovery of the mitochondrial function.
    Date: 2024-08
    Relation: Nano Letters. 2024 Aug;24(36):11202-11209.
    Link to: http://dx.doi.org/10.1021/acs.nanolett.4c02331
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1530-6984&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001308486200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85202771037
    Appears in Collections:[Shu-Yi Lin] Periodical Articles

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