RATIONALE: Ambient air pollution has been associated with adverse respiratory outcomes, especially among children with asthma. Little is known about the relationships between early postnatal exposure to particulate matter of 2.5 mm or less (PM2.5) and airway resistance among asthmatic children. We aimed to evaluate whether early postnatal exposure to PM2.5 was associated with airway resistance among school-age children with asthma. METHODS: The study included 267 full-term (>_37 weeks of gestation) school-age children with asthma (163 boys, 61%), part of the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort. Airway resistance was measured by impulse oscillometry. Exposure to PM2.5 was estimated by linking subjects’ residential addresses during the first year of life to air quality monitoring stations operated by Taiwan Air Quality Monitoring Network. Multiple linear regressions with covariates adjustment were used to examine the association of PM2.5 exposure during the first year of life with airway resistance. RESULTS: Higher PM2.5 exposure during the first year of life was significantly associated with both increased total airway resistance (R5) (b: 0.074 per 1 mg/m3 , p 50.031) and proximal airway resistance (R20) (b: 0.062, p 50.016). Sex-stratified analysis showed an association of higher PM2.5 exposure during the first year of life with increased total airway resistance (R5) (b: 0.111, p 50.034) and proximal airway resistance (R20) (b: 0.090, p 50.038) among girls, but not among boys. CONCLUSIONS: 這項研究表明,學齡哮喘兒童(尤其是女孩)出生後 早期接觸 PM 2.5與氣道阻力增加有關。
Date:
2024-02
Relation:
Journal of Allergy and Clinical Immunology. 2024 Feb;153(2, Suppl.):Meeting Abstract AB190.
