國家衛生研究院 NHRI:Item 3990099045/16074
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 908955      在线人数 : 1010
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/16074


    题名: Body mass index and risk of colorectal cancer incidence and mortality in Asia
    作者: Paragomi, P;Zhang, Z;Abe, SK;Islam, MR;Rahman, MS;Saito, E;Shu, XO;Dabo, B;Pham, YT;Chen, Y;Gao, YT;Koh, WP;Sawada, N;Malekzadeh, R;Sakata, R;Hozawa, A;Kim, J;Kanemura, S;Nagata, C;You, SL;Ito, H;Park, SK;Yuan, JM;Pan, WH;Wen, W;Wang, R;Cai, H;Tsugane, S;Pourshams, A;Sugawara, Y;Wada, K;Chen, CJ;Oze, I;Shin, A;Ahsan, H;Boffetta, P;Chia, KS;Matsuo, K;Qiao, YL;Rothman, N;Zheng, W;Inoue, M;Kang, D;Luu, HN
    贡献者: Institute of Population Health Sciences
    摘要: IMPORTANCE: The global burden of obesity is increasing, as are colorectal cancer (CRC) incidence and mortality. OBJECTIVES: To assess the association between body mass index (BMI) and risks of incident CRC and CRC-related death in the Asian population. DESIGN, SETTING, AND PARTICIPANTS: This cohort study includes data pooled from 17 prospective cohort studies included in The Asia Cohort Consortium. Cohort enrollment was conducted from January 1, 1984, to December 31, 2002. Median follow-up time was 15.2 years (IQR, 12.1-19.2 years). Data were analyzed from January 15, 2023, through January 15, 2024. EXPOSURE: Body mass index, calculated as weight in kilograms divided by height in meters squared. MAIN OUTCOMES AND MEASURES: The primary outcomes were CRC incidence and CRC-related mortality. The risk of events is reported as adjusted hazard ratios (AHRs) and 95% CIs for incident CRC and death from CRC using the Cox proportional hazards regression model. RESULTS: To assess the risk of incident CRC, 619 981 participants (mean [SD] age, 53.8 [10.1] years; 52.0% female; 11 900 diagnosed incident CRC cases) were included in the study, and to assess CRC-related mortality, 650 195 participants (mean [SD] age, 53.5 [10.2] years; 51.9% female; 4550 identified CRC deaths) were included in the study. A positive association between BMI and risk of CRC was observed among participants with a BMI greater than 25.0 to 27.5 (AHR, 1.09 [95% CI, 1.03-1.16]), greater than 27.5 to 30.0 (AHR, 1.19 [95% CI, 1.11-1.29]), and greater than 30.0 (AHR, 1.32 [95% CI, 1.19-1.46]) compared with those with a BMI greater than 23.0 to 25.0 (P < .001 for trend), and BMI was associated with a greater increase in risk for colon cancer than for rectal cancer. A similar association between BMI and CRC-related death risk was observed among participants with a BMI greater than 27.5 (BMI >27.5-30.0: AHR, 1.18 [95% CI, 1.04-1.34]; BMI >30.0: AHR, 1.38 [95% CI, 1.18-1.62]; P < .001 for trend) and was present among men with a BMI greater than 30.0 (AHR, 1.87 [95% CI, 1.49-2.34]; P < .001 for trend) but not among women (P = .15 for trend) (P = .02 for heterogeneity). CONCLUSIONS AND RELEVANCE: In this cohort study that included a pooled analysis of 17 cohort studies comprising participants across Asia, a positive association between BMI and CRC incidence and related mortality was found. The risk was greater among men and participants with colon cancer. These findings may have implications to better understand the burden of obesity on CRC incidence and related deaths in the Asian population.
    日期: 2024-08-01
    關聯: JAMA Network Open. 2024 Aug 01;7(8):Article number e2429494.
    Link to: http://dx.doi.org/10.1001/jamanetworkopen.2024.29494
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2574-3805&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001302987400005
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85202759249
    显示于类别:[潘文涵] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB39196559.pdf1061KbAdobe PDF43检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈