國家衛生研究院 NHRI:Item 3990099045/16019

NHRI > National Institute of Environmental Health Sciences > Lukas Jyuhn-Hsiarn Lee > Periodical Articles > Item 3990099045/16019

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16019

Title:	Elevated reactive aggression in forebrain-specific Ccn2 knockout mice
Authors:	Chang, HC;Ng, CH;Chen, YF;Wang, YC;Yu, IS;Lee, LJH;Lee, LJ;Lee, KY
Contributors:	National Institute of Environmental Health Sciences
Abstract:	Cellular communication network factor 2 (CCN2) is a matricellular protein that plays important roles in connective tissue. CCN2 is also expressed in the nervous system; however, its role is still unclear. To explore CCN2 function in the brain, we generated forebrain-specific Ccn2 knockout (FbCcn2 KO) mice. In this study, we examined the behavioral phenotypes of FbCcn2KO mice. Male mice lacking CCN2 in the forebrain exhibited normal locomotion, sensorimotor gating, and social behaviors but signs of anxiety and elevated reactive aggression. We checked the c-fos expression in aggression-related brain regions following the resident-intruder task (RIT), an aggression test. RIT-induced c-fos levels in the medial amygdala (MeA) were higher in FbCcn2−/− mice as compared to controls. However, in the prefrontal cortex, RIT-induced c-fos levels in FbCcn2−/− mice were lower than controls. Our results suggested in male mice lacking CCN2 in the olfaction-related regions, olfactory social cues elicit greater signals in the MeA, resulting in greater reactive aggression in the RIT. Further, lacking CCN2 in the prefrontal cortex, the major area related to inhibitory control and emotion regulation, may lead to signs of anxiety and the failure to suppress aggressive behaviors. Our model is useful in elaborating the mechanism underlying reactive aggression and therapeutic strategies.
Date:	2024-07-20
Relation:	Journal of Cell Communication and Signaling. 2024 Jul 20;Article in Press.
Link to:	http://dx.doi.org/10.1002/ccs3.12040
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1873-9601&DestApp=IC2JCR
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85198928857
Appears in Collections:	[Lukas Jyuhn-Hsiarn Lee] Periodical Articles

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