國家衛生研究院 NHRI:Item 3990099045/15846
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15846


    Title: MMP-9 upregulation may predict hemorrhagic transformation after endovascular thrombectomy
    Authors: Huang, JA;Wu, YH;Chen, PL;Weng, YC;Chiang, IC;Huang, YT;Chou, WH
    Contributors: Center for Neuropsychiatric Research
    Abstract: Background Hemorrhagic transformation (HT) is a serious complication after endovascular thrombectomy (EVT) for patients with acute ischemic stroke (AIS). We analyzed the plasma levels of MMP-9 before and after EVT and assessed the temporal changes of MMP-9 that may be associated with, and therefore predict, HT after EVT.Methods We enrolled 30 AIS patients who received EVT, and 16 (53.3%) developed HT. The levels of MMP-9 in plasma collected from the arteries of AIS patients before and immediately after EVT were measured using ELISA. The percent change in MMP-9 after EVT (after/before) was calculated and compared between patients with and without HT.Results The median age of the AIS patients was 70 years, and 13 patients (43.3%) were men. The median National Institutes of Health Stroke Scale (NIHSS) scores of patients with HT were 18 on admission and 18 after EVT. The median NIHSS scores of patients without HT were 17 on admission and 11 after EVT. Patients with HT demonstrated significantly greater percentage increases in arterial MMP-9 levels after EVT.Conclusion Patients with AIS who developed HT had significantly increased arterial MMP-9 levels after EVT, suggesting that the upregulation of MMP-9 following EVT could serve as a predictive biomarker for HT.
    Date: 2024-05-09
    Relation: Frontiers in Neurology. 2024 May 09;15:Article number 1400270.
    Link to: http://dx.doi.org/10.3389/fneur.2024.1400270
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-2295&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001229004600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85193853557
    Appears in Collections:[Wen-Hai Chou] Periodical Articles

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