國家衛生研究院 NHRI:Item 3990099045/15818

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15818

Title:	Pulse pressure is associated with decline in physical function in older adults
Authors:	Chuang, SY;Liu, WL;Cheng, HM;Chung, RH;Lai, CH;Chuang, SC;Wu, IC;Chang, HY;Hsiung, CA;Chen, WJ;Hsu, CC
Contributors:	Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research;Center for Neuropsychiatric Research
Abstract:	Objectives: This study examined the associations between pulse pressure, hypertension, and the decline in physical function in a prospective framework. Study design: The Healthy Aging Longitudinal Study tracked a group of Taiwanese adults aged 55 or more over an average of 6.19 years to assess pulse pressure and decline in physical function, including in handgrip strength, gait speed, and 6-min walking distance, at baseline (2009–2013) and in the second phase of assessments (2013−2020). Main outcome measures: Pulse pressure was calculated as the difference between systolic and diastolic blood pressure values. Weakness, slowness, and low endurance were defined as decreases of ≥0.23 m/s (one standard deviation) in gait speed, ≥5.08 kg in handgrip strength, and ≥ 57.73 m in a 6-min walk, as determined from baseline to the second phase of assessment. Linear and logistic regressions were employed to evaluate the associations between pulse pressure, hypertension, and decline in physical function. Results: Baseline pulse pressure was associated with future handgrip strength (beta = −0.017, p = 0.0362), gait speed (beta = −0.001, p < 0.0001), and 6-min walking distance (beta = −0.470, p < 0001). In multivariable models, only handgrip strength (beta = −0.016, p = 0.0135) and walking speed (beta = −0.001, p = 0.0042) remained significantly associated with future pulse pressure. Older adults with high systolic blood pressure (≥140 mmHg) and elevated pulse pressure (≥60 mmHg) exhibited a significantly increased risk of weakness (odds ratio: 1.30, 95 % confidence interval: 1.08–1.58), slowness (1.29, 1.04–1.59), and diminished endurance (1.25, 1.04–1.50) compared with the reference group, who exhibited systolic blood pressure of <140 mmHg and pulse pressure of <60 mmHg. Conclusions: Among older adults, pulse pressure is associated with a decline in physical function, especially in terms of strength and locomotion.
Date:	2024-07
Relation:	Maturitas. 2024 Jul;185:Article number 108000.
Link to:	http://dx.doi.org/10.1016/j.maturitas.2024.108000
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0378-5122&DestApp=IC2JCR
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85190985309
Appears in Collections:	[Chih-Cheng Hsu] Periodical Articles [Chih-Cheng Hsu] Periodical Articles [Chao A. Hsiung] Periodical Articles [Hsing-Yi Chang] Periodical Articles [I-Chien Wu] Periodical Articles [Shu-Chun Chuang] Periodical Articles [Ren-Hua Chung] Periodical Articles [Shao-Yuan Chuang] Periodical Articles [Wei-J. Chen] Periodical Articles

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