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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/15780
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| Title: | The efficacy of multi-disciplinary lifestyle modifications in Taiwanese nonalcoholic steatohepatitis patients |
| Authors: | Yeh, ML;Dai, CY;Huang, CF;Huang, SF;Tsai, PC;Hsu, PY;Huang, C;Wei, YJ;Liang, PC;Bair, MJ;Lee, MH;Lin, ZY;Huang, JF;Yu, ML;Chuang, WL |
| Contributors: | Institute of Molecular and Genomic Medicine |
| Abstract: | Lifestyle modification is the standard of care for nonalcoholic fatty liver disease (NAFLD) patients. We aimed to investigate the efficacy of a short-term lifestyle modification program in the disease course of Taiwanese nonalcoholic steatohepatitis (NASH) patients with paired biopsies. All patients received a 6-month, strict multidisciplinary program of lifestyle modifications led by physicians, dieticians, and nursing staff. The histopathological and clinical features were assessed. The endpoints were normalization of transaminase levels, metabolic parameters, a decrease in the NAFLD activity score (NAS) >= 1, and a decrease in the fibrosis stage >= 1. We also aimed to elucidate the predictors associated with disease progression. A total of 37 patients with biopsy-proven NASH were enrolled. The normalization of transaminase levels increased from 0% to 13.5%. There were also significantly increased proportions of patients with normal total cholesterol, triglyceride, and hemoglobin A1c levels. Fifteen (40.5%) patients had an increased NAS >= 1, whereas 10 (27.0%) patients had NAS regression. Twelve (32.4%) patients had increased fibrosis >= 1 stage. Only 2 (5.4%) patients experienced fibrosis regression. A high fasting plasma glucose (FPG) level was associated with NAS progression. Older age and higher transaminase and FPG levels were factors associated with fibrosis progression. Seven (18.9%) patients achieved a body weight reduction >3%, and 4 (57.1%) of them experienced NAS regression. No significant effect of weight reduction on the progression of fibrosis was observed. The short-term lifestyle modification program significantly decreased liver enzymes and metabolic parameters in NASH patients. A more precise or intensive program may be needed for fibrosis improvement. |
| Date: | 2024-04-16 |
| Relation: | Kaohsiung Journal of Medical Sciences. 2024 Apr 16;Article in Press. |
| Link to: | http://dx.doi.org/10.1002/kjm2.12833 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1607-551X&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001203631700001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85190973651 |
| Appears in Collections: | [黃秀芬] 期刊論文
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| ISI001203631700001.pdf | | 1477Kb | Adobe PDF | 46 | View/Open |
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