國家衛生研究院 NHRI:Item 3990099045/15721

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Title:	Association between maternal folic acid supplementation during pregnancy and childhood allergic diseases among Asian children
Authors:	Hung, CY;Tsai, ZT;Tsai, HJ;Yao, TC
Contributors:	Institute of Population Health Sciences
Abstract:	Background: Previous studies have suggested a relationship between maternal folic acid supplementation during pregnancy and allergic diseases in early childhood, but the results of epidemiological studies are conflicting. This study aimed to investigate the association of maternal folic acid supplementation during pregnancy with childhood allergic diseases and allergic sensitization among Asian children. Method: A total of 1513 children (850 boys, 56.2%; mean age, 6.4 years) participated in the Longitudinal Investigation of Global Health in Taiwanese School children (LIGHTS) cohort were enrolled in this study. Information on demographics, maternal folic acid supplementation during pregnancy, childhood allergic diseases, and relevant covariates was obtained by parent-reported questionnaires. Allergic diseases, including asthma, allergic rhinitis, and atopic eczema were defined by physician diagnosis and the presence of corresponding symptoms in the last 12 months. Allergic sensitization was determined by Phadiatop Infant. Results: Maternal folic acid supplementation during pregnancy was significantly associated with increased risk of allergic rhinitis (adjusted odds ratio [AOR]: 1.39; 95% confidence interval [CI]: 1.05–1.85), after adjusting for relevant confounders. We found no evidence for significant association of maternal folic acid supplementation during pregnancy with asthma (AOR: 1.30; 95% CI: 0.77–2.19), atopic eczema (AOR: 1.04; 95% CI: 0.73–1.48), or allergic sensitization (AOR: 0.77; 95% CI: 0.57–1.03). Conclusion: This study provides supportive evidence that maternal folic acid supplementation during pregnancy was significantly associated with 1.4-fold increased risk of allergic rhinitis by the age of 6 years, but not asthma, atopic eczema, or allergic sensitization, among Asian children in Taiwan.
Date:	2023-12-28
Relation:	Allergy. 2023 Dec 28;78(Suppl. 112):545-546.
Link to:	http://dx.doi.org/10.1111/all.15925
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
Appears in Collections:	[Hui-Ju Tsai] Conference Papers/Meeting Abstract

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