國家衛生研究院 NHRI:Item 3990099045/1567
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1567


    Title: High prevalence of hyperuricemia in elderly Taiwanese
    Authors: Lee, MS;Lin, SC;Chang, HY;Lyu, LC;Tsai, KS;Pan, WH
    Contributors: Center for Health Policy Research and Development
    Abstract: Serum urate status, the prevalence of hyperuricemia and their relationship to the metabolic syndrome in elderly Taiwanese were described using data from the Elderly Nutrition and Health Survey in Taiwan (1999-2000), in which a stratified multi-stage clustered sampling scheme was applied. Complete data from biochemical assays and anthropometric measures for 1225 males and 1167 females were included in the analysis. The mean urate level and 95% confidence interval was 411 (398, 424) mu M for males and 357 (347, 367) mu M for females. Males had significantly higher serum urate levels than females across all age groups (P <0.05). No significant difference in mean serum urate was found among the four age groups of males. On the other hand, females of 75-79 years had significantly higher serum urate levels (376 mu M) than that of the 65-69 and 80 age groups. The overall prevalence of hyperuricemia (>= 416.7 mu M (7.0 mg/dL) in the elderly was 36% (46% for males and 26% for females). Among the participants, 4.2% of males and 1.1% of females were taking medication to lower uric acid. The elderly (males 455 mu M; females 416 mu M) of the Mountain areas, mainly indigenes, had the highest mean serum urate overall, however, the highest prevalence of hyperuricemia in males was found in the PengHu islands (62%) and that for females in the Mountain areas (51%). The odds ratio (OR) for hyperuricemia was 2.84 for males in the PengHu islands and 4.33 for females in Mountain areas, compared with their counterparts in the third stratum in the northern areas. Adjusting for obesity, alcohol and other related covariates did not alter the relative rank of the ORs in the various strata. Elderly males (22%) had a significantly lower rate of metabolic syndrome (MS) than females (39%) (P <0.05). For both genders, those with MS had a significantly higher mean serum urate (males 436 mu M vs. 405 mu M; females 389 mu M vs. 338 mu M) and prevalence of hyperuricemia (males 56% vs. 43%; females 38% vs. 19%) (P <0.05). The population attributable risk for MS from hyperuricemia was 18.8% in men and 15.5% in women. In conclusion, the mean serum urate and prevalence of hyperuricemia in the elderly in Taiwan were higher than those found in other populations and was significantly associated with MS. Gene-environmental interaction may play a key role since great geo-graphical variation exists within various Han Chinese groups in Taiwan and between Han Chinese and Taiwanese indigenes.
    Keywords: Nutrition & Dietetics
    Date: 2005
    Relation: Asia Pacific Journal of Clinical Nutrition. 2005;14(3):285-292.
    Link to: http://apjcn.nhri.org.tw/server/APJCN/Volume14/vol14.3/fullArticles/index.htm
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0964-7058&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000232098600013
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=25444493633
    Appears in Collections:[Hsing-Yi Chang] Periodical Articles

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