國家衛生研究院 NHRI:Item 3990099045/15634
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    题名: Shared genetic architectures of educational attainment in East Asian and European populations
    作者: Chen, TT;Kim, J;Lam, M;Chuang, YF;Chiu, YL;Lin, SC;Jung, SH;Kim, B;Kim, S;Cho, C;Shim, I;Park, S;Ahn, Y;Okbay, A;Jang, H;Kim, HJ;Seo, SW;Park, WY;Ge, T;Huang, H;Feng, YCA;Lin, YF;Myung, W;Chen, CY;Won, HH
    贡献者: Center for Neuropsychiatric Research
    摘要: Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345). EduYears showed a high genetic correlation and power-adjusted transferability ratio between EAS and EUR. We also found similar functional enrichment, gene expression enrichment and cross-trait genetic correlations between two populations. Cross-ancestry fine-mapping identified refined credible sets with a higher posterior inclusion probability than single population fine-mapping. Polygenic prediction analysis in four independent EAS and EUR cohorts demonstrated transferability between populations. Our study supports the need for further research on diverse ancestries to increase our understanding of the genetic basis of educational attainment.
    日期: 2024-03
    關聯: Nature Human Behaviour. 2024 Mar;8(3):562-575.
    Link to: http://dx.doi.org/10.1038/s41562-023-01781-9
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2397-3374&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001137082600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85181680141
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