國家衛生研究院 NHRI:Item 3990099045/15627
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    題名: Detection of toxigenic M1(UK) lineage group A Streptococcus clones in Taiwan
    作者: Chuan, CN;Hsu, CY;Yeh, YH;Chi, CY;Wang, S;Tsai, PJ;Chiu, CH
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: BACKGROUND: A new sublineage of emm1 group A Streptococcus (GAS), M1(UK), has emerged in Europe, North America, and Australia. Notably, a significant portion of emm1 isolates in Asia, particularly in Hong Kong and mainland China, acquired scarlet fever-associated prophages following the 2011 Hong Kong scarlet fever outbreak. However, the presence of the M1(UK) sublineage has not yet been detected in Asia. METHODS: This study included 181 GAS isolates (2011-2021). The emm type of these isolates were determined, and 21 emm1 isolates from blood or pleural fluid (2011-2021) and 10 emm1 isolates from throat swabs (2016-2018) underwent analysis. The presence of the scarlet fever-associated prophages and the specific single nucleotide polymorphisms of the M1(UK) clone were determined by polymerase chain reaction and the genome sequencing. RESULTS: The M1(UK) lineage strains from throat swab and blood samples were identified. One of the M1(UK) strain in Taiwan carried the scarlet fever-associated prophage and therefore acquired the ssa, speC, and spd1 toxin repertoire. Nonetheless, the increase of M1(UK) was not observed until 2021, and there was a reduction in the diversity of emm types in 2020-2021, possibly due to the COVID-19 pandemic restriction policies in Taiwan. CONCLUSIONS: Our results suggested that the M1(UK) lineage clone has introduced in Taiwan. In Taiwan, the COVID-19 restrictions were officially released in March 2023; therefore, it would be crucial to continuously monitor the M1(UK) expansion and its related diseases in the post COVID-19 era.
    日期: 2024-04
    關聯: Journal of Microbiology, Immunology, and Infection. 2024 Apr;57(2):269-277.
    Link to: http://dx.doi.org/10.1016/j.jmii.2024.01.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1684-1182&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85183666635
    顯示於類別:[齊嘉鈺] 期刊論文

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