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http://ir.nhri.org.tw/handle/3990099045/15627
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| Title: | Detection of toxigenic M1(UK) lineage group A Streptococcus clones in Taiwan |
| Authors: | Chuan, CN;Hsu, CY;Yeh, YH;Chi, CY;Wang, S;Tsai, PJ;Chiu, CH |
| Contributors: | National Institute of Infectious Diseases and Vaccinology |
| Abstract: | BACKGROUND: A new sublineage of emm1 group A Streptococcus (GAS), M1(UK), has emerged in Europe, North America, and Australia. Notably, a significant portion of emm1 isolates in Asia, particularly in Hong Kong and mainland China, acquired scarlet fever-associated prophages following the 2011 Hong Kong scarlet fever outbreak. However, the presence of the M1(UK) sublineage has not yet been detected in Asia. METHODS: This study included 181 GAS isolates (2011-2021). The emm type of these isolates were determined, and 21 emm1 isolates from blood or pleural fluid (2011-2021) and 10 emm1 isolates from throat swabs (2016-2018) underwent analysis. The presence of the scarlet fever-associated prophages and the specific single nucleotide polymorphisms of the M1(UK) clone were determined by polymerase chain reaction and the genome sequencing. RESULTS: The M1(UK) lineage strains from throat swab and blood samples were identified. One of the M1(UK) strain in Taiwan carried the scarlet fever-associated prophage and therefore acquired the ssa, speC, and spd1 toxin repertoire. Nonetheless, the increase of M1(UK) was not observed until 2021, and there was a reduction in the diversity of emm types in 2020-2021, possibly due to the COVID-19 pandemic restriction policies in Taiwan. CONCLUSIONS: Our results suggested that the M1(UK) lineage clone has introduced in Taiwan. In Taiwan, the COVID-19 restrictions were officially released in March 2023; therefore, it would be crucial to continuously monitor the M1(UK) expansion and its related diseases in the post COVID-19 era. |
| Date: | 2024-04 |
| Relation: | Journal of Microbiology, Immunology, and Infection. 2024 Apr;57(2):269-277. |
| Link to: | http://dx.doi.org/10.1016/j.jmii.2024.01.004 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1684-1182&DestApp=IC2JCR |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85183666635 |
| Appears in Collections: | [齊嘉鈺] 期刊論文
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| PUB38278671.pdf | | 1778Kb | Adobe PDF | 58 | View/Open |
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