國家衛生研究院 NHRI:Item 3990099045/15585
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    题名: The effect of paraben exposures on children with asthma
    作者: Wang, IJ;Chang, JW;Huang, PC
    贡献者: National Institute of Environmental Health Sciences
    摘要: Background: Evidence has shown that parabens, as an antiseptic in food, medicine and cosmetics, may increase allergic contact dermatitis. However, the relationship between the use of parabens and allergic diseases in children is not fully elucidated. We aim to assess the association between parabens exposure and oxidative stress markers in children with asthma. Evidence has shown that parabens, as an antiseptic in food, medicine and cosmetics, may increase allergic contact dermatitis. However, the relationship between the use of parabens and allergic diseases in children is not fully elucidated. We aim to assess the association between parabens exposure and oxidative stress markers in children with asthma. Method: We recruited 138 children with clinically diagnosed asthma and 82 normal children as controls from a hospital. Urine parabens including methyl paraben (MeP), ethyl paraben (EtP), n-propyl paraben (PrP), n-butyl paraben (BuP), and etc. were measured by an automatic, high throughput online SPE–LC–MS/MS method. Urine 8-hydroxy-2-deoxyguanosine (8-OHdG), an oxidative stress marker, was measured by LC–MS/MS. Urine malondialdehyde (MDA) was measured by ELISA. Demographic characteristics including developmental status, disease history, lifestyle, and exposure sources were also collected by questionnaires. Linear regression was applied to estimate the association between parabens exposure and stress marker levels. Logistic regression was used to estimate the association between paraben exposure and asthma. Results: Family income in control was significantly higher than that in asthma children (p = 0.015). Meanwhile, the median levels of urinary Methyl Paraben (418.24 vs. 408.90 μg/L), Ethyl Paraben (36.26 vs. 35.68 μg/L) and Propyl Paraben (101.12 vs. 95.39 μg/L) in asthma children were higher than those in control. The median levels of urinary MDA (6.36 vs. 6.24 μM) in case group were higher than those in control, though failed to reach statistically significance. Urinary Methyl Paraben was significant with the other parabens which indicated a common exposure source. Conclusion: Parabens may increase the risk of asthma. The oxidative stress biomarker was significantly associated with asthma, while the lipid peroxidation marker failed to reach statistical significance. Further large sample is warranted to prove if the effect of parabens on asthma was mediated by the oxidative stress.
    日期: 2023-02
    關聯: Allergy. 2023 Feb;78:33.
    Link to: http://dx.doi.org/10.1111/all.15614
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
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