國家衛生研究院 NHRI:Item 3990099045/15564

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15564

Title:	Evolution of influenza A(H3N2) viruses in 2 consecutive seasons of genomic surveillance, 2021–2023
Authors:	Fall, A;Han, L;Yunker, M;Gong, YN;Li, TJ;Norton, JM;Abdullah, O;Rothman, RE;Fenstermacher, KZJ;Paul Morris, C;Pekosz, A;Klein, E;Mostafa, HH
Contributors:	National Institute of Infectious Diseases and Vaccinology
Abstract:	Background. The circulation and the genomic evolution of influenza A(H3N2) viruses during the 2021/2022 and 2022/2023 seasons were studied and associated with infection outcomes. Methods. Remnant influenza A–positive samples following standard-of-care testing from patients across the Johns Hopkins Health System (JHHS) were used for the study. Samples were randomly selected for whole viral genome sequencing. The sequence-based pEpitope model was used to estimate the predicted vaccine efficacy (pVE) for circulating H3N2 viruses. Clinical data were collected and associated with viral genomic data. Results. A total of 121 683 respiratory specimens were tested for influenza at JHHS between 1 September 2021 and 31 December 2022. Among them, 6071 (4.99%) tested positive for influenza A. Of these, 805 samples were randomly selected for sequencing, with hemagglutinin (HA) segments characterized for 610 samples. Among the characterized samples, 581 were H3N2 (95.2%). Phylogenetic analysis of HA segments revealed the exclusive circulation of H3N2 viruses with HA segments of the 3C.2a1b.2a.2 clade. Analysis of a total of 445 complete H3N2 genomes revealed reassortments; 200 of 227 of the 2022/2023 season genomes (88.1%) were found to have reassorted with clade 3C.2a1b.1a. The pVE was estimated to be −42.53% for the 2021/2022 season and 30.27% for the 2022/2023 season. No differences in clinical presentations or admissions were observed between the 2 seasons. Conclusions. The increased numbers of cases and genomic diversity of influenza A(H3N2) during the 2022/2023 season were not associated with a change in disease severity compared to the previous influenza season.
Date:	2023-12
Relation:	Open Forum Infectious Diseases. 2023 Dec;10(12):Article number ofad577.
Link to:	http://dx.doi.org/10.1093/ofid/ofad577
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2328-8957&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001124795600005
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85180267491
Appears in Collections:	[Others] Periodical Articles

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