國家衛生研究院 NHRI:Item 3990099045/15536
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15536


    Title: The prognosis performance of a neutrophil- and lymphocyte-associated gene mutation score in a head and neck cancer cohort
    Authors: Yeh, TJ;Wang, HC;Cho, SF;Wu, CC;Hsieh, TY;Huang, CT;Wang, MH;Chuang, TM;Gau, YC;Du, JS;Liu, YC;Hsiao, HH;Pan, MR;Chen, LT;Moi, SH
    Contributors: National Institute of Cancer Research
    Abstract: The treatment of head and neck squamous cell carcinomas (HNSCCs) is multimodal, and chemoradiotherapy (CRT) is a critical component. However, the availability of predictive or prognostic markers in patients with HNSCC is limited. Inflammation is a well-documented factor in cancer, and several parameters have been studied, with the neutrophil-to-lymphocyte ratio (NLR) being the most promising. The NLR is the most extensively researched clinical biomarker in various solid tumors, including HNSCC. In our study, we collected clinical and next-generation sequencing (NGS) data with targeted sequencing information from 107 patients with HNSCC who underwent CRT. The difference in the NLR between the good response group and the poor response group was significant, with more patients having a high NLR in the poor response group. We also examined the genetic alterations linked to the NLR and found a total of 41 associated genes across eight common pathways searched from the KEGG database. The overall mutation rate was low, and there was no significant mutation difference between the low- and high-NLR groups. Using a multivariate binomial generalized linear model, we identified three candidate genes (MAP2K2, MAP2K4, and ABL1) that showed significant results and were used to create a gene mutation score (GMS). Using the NLR-GMS category, we noticed that the high-NLR-GMS group had significantly shorter relapse-free survival compared to the intermediate- or low-NLR-GMS groups.
    Date: 2023-11-22
    Relation: Biomedicines. 2023 Nov 22;11(12):Article number 120209.
    Link to: http://dx.doi.org/10.3390/biomedicines11123113
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2227-9059&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001131067500001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85180730463
    Appears in Collections:[Li-Tzong Chen] Periodical Articles

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