國家衛生研究院 NHRI:Item 3990099045/15472
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    题名: An integrated microfluidic device for automated detection of cancer cells from bile for cholangiocarcinoma prognosis
    作者: Chang, JL;Tsai, YC;Chiang, NJ;Huang, CJ;Huang, YS;Hung, SC;Shan, YS;Lee, GB
    贡献者: National Institute of Cancer Research
    摘要: Cholangiocarcinoma (CCA) is difficult to detect due to its deep location and has recognized as “silent” cancer. Blood has been commonly used for liquid biopsy; however, accuracy of this approach was not satisfactory. In this study, we hypothesized bile could be a reliable sample for CCA detection/prognosis since it is relatively closer to lesions. We herein developed a new integrated microfluidic system which could simultaneously utilize three affinity reagents to capture tumor cells. Experimental results showed these affinity reagents captured tumor cells successfully in 2-ml bile with a sensitivity of 100% and a specificity of 79.3% from 119 clinical samples.
    日期: 2022-10
    關聯: MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. 2022 Oct:229-230.
    Link to: https://www.microtas2022.org/files/MicroTAS2022_Program.pdf
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85175696841
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