國家衛生研究院 NHRI:Item 3990099045/15452
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    題名: Fruits are vehicles of drug-resistant pathogenic Candida tropicalis
    作者: Chen, YZ;Tseng, KY;Wang, SC;Huang, CL;Lin, CC;Zhou, ZL;Tsai, DJ;Lin, CM;Chen, YL;Chen, KT;Liao, YC;Chen, FJ;Sytwu, HK;Lan, CY;Lo, HJ
    貢獻者: National Institute of Infectious Diseases and Vaccinology;Institute of Population Health Sciences
    摘要: Candida tropicalis is the leading cause of non-albicans candidemia in tropical/sub-tropical areas. We detected a predominant genotype of azole-resistant C. tropicalis clinical strains in Taiwan from 2014 to 2018. To investigate the potential fomite transmission of drug-resistant C. tropicalis, we characterized yeasts recovered from 17 samples sourced from 6 different kinds of fruits from a supermarket in northern Taiwan in the present study. Fruits were gently washed with buffer, and the solution was then collected for centrifugation. The cell suspension was plated onto CHROMagar Candida medium. Representative yeast species was identified by rDNA sequencing. Drug susceptibilities of C. tropicalis were determined by the broth microdilution method. We found that different types of fruit surfaces had different distributions of yeast species. Washing fruit can significantly eliminate the number of yeasts from the surface. Of 123 identified isolates, C. tropicalis was the most frequently found species, followed by Meyerozyma caribbica and Candida krusei. Among 10 collected C. tropicalis, all 3 fluconazole-resistant ones were non-susceptible to voriconazole. Furthermore, the genotype of all azole-resistant C. tropicalis belonged to the same predominant genotype of azole-resistant C. tropicalis causing candidemia in patients in Taiwan. Hence, fruit can serve as a vehicle of azole-resistant C. tropicalis and other species, especially C. krusei, which is intrinsically resistant to fluconazole.
    日期: 2023-12
    關聯: Microbiology Spectrum. 2023 Dec 12;11(6):Article number e0147123.
    Link to: http://dx.doi.org/10.1128/spectrum.01471-23
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2165-0497&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001099067300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85180011589
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