國家衛生研究院 NHRI:Item 3990099045/15420
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    题名: MicroRNA regulators of vascular pathophysiology in chronic kidney disease
    作者: Wu, KL;Chen, CL;Thi Nguyen, MH;Tsai, JC;Wang, SC;Chiang, WF;Hsiao, PJ;Chan, JS;Hou, JJ;Ma, N
    贡献者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Coronary artery disease (CAD) is a severe comorbidity in chronic kidney disease (CKD) due to heavy calcification in the medial layer and inflamed plaques. Chronic inflammation, endothelial dysfunction and vascular calcification are major contributors that lead to artherosclerosis in CKD. The lack of specific symptoms and signs of CAD and decreased accuracy of noninvasive diagnostic tools result in delayed diagnosis leading to increased mortality. MicroRNAs (miRNAs) are post-transcriptional regulators present in various biofluids throughout the body. In the circulation, miRNAs have been reported to be encapsulated in extracellular vesicles and serve as stable messengers for crosstalk among cells. miRNAs are involved in pathophysiologic mechanisms including CAD and can potentially be extended from basic research to clinical translational practice.
    日期: 2023-11-01
    關聯: Clinica Chimica Acta. 2023 Nov 1;551:Article number 117610.
    Link to: http://dx.doi.org/10.1016/j.cca.2023.117610
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-8981&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001092247700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85174704299
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