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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/15415
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| Title: | Cartilage oligomeric matrix protein overexpression is an independent poor prognostic indicator in patients with intrahepatic cholangiocarcinoma |
| Authors: | Ong, KH;Hsieh, YY;Lai, HY;Sun, DP;Chen, TJ;Huang, SKH;Tian, YF;Chou, CL;Shiue, YL;Wu, HC;Chan, TC;Tsai, HH;Li, CF;Su, PA;Kuo, YH |
| Contributors: | National Institute of Cancer Research |
| Abstract: | Cartilage oligomeric matrix protein (COMP) interacts with various extracellular matrix proteins in tissues. Elevated COMP levels recently linked to worse overall survival in multiple cancer types. COMP's significance in intrahepatic cholangiocarcinoma (iCCA) remains uncertain. Here we report a retrospective study to explore COMP's impact on iCCA outcomes. We collected 182 patients' iCCA tumor tissues. COMP overexpression was associated with adverse factors like R1 resection (p = 0.008), advanced T stage (p < 0.001), large duct type (p = 0.004), and poorly differentiated histology (p = 0.002). COMP overexpression correlates with poorer DFS (HR, 3.651; p = 0.001), OS (HR, 1.827; p = 0.023), LRFS (HR, 4.077; p < 0.001), and MFS (HR, 3.718; p < 0.001). High COMP expression ties to worse overall survival (p = 0.0001), DSS (p < 0.0001), LRFS (p < 0.0001), and MFS (p < 0.0001). In conclusion, COMP overexpression links to poor prognosis and pathological features in iCCA, indicating its potential as a biomarker. |
| Date: | 2023-10-14 |
| Relation: | Scientific Reports. 2023 Oct 14;13:Article number 17444. |
| Link to: | http://dx.doi.org/10.1038/s41598-023-43006-z |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001085058900041 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85174251287 |
| Appears in Collections: | [其他] 期刊論文
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| SCP85174251287.pdf | | 2508Kb | Adobe PDF | 107 | View/Open |
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