國家衛生研究院 NHRI:Item 3990099045/15385
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 906032      Online Users : 648
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15385


    Title: Whole genome sequencing analysis of body mass index identifies novel african ancestry-specific risk allele
    Authors: Zhang, X;Brody, JA;Graff, M;Highland, HM;Chami, N;Xu, H;Wang, Z;Ferrier, K;Chittoor, G;Josyula, NS;Li, X;Li, Z;Allison, MA;Becker, DM;Bielak, LF;Bis, JC;Boorgula, MP;Bowden, DW;Broome, JG;Buth, EJ;Carlson, CS;Chang, KM;Chavan, S;Chiu, YF;Chuang, LM;Conomos, MP;DeMeo, DL;Du, M;Duggirala, R;Eng, C;Fohner, AE;Freedman, BI;Garrett, ME;Guo, X;Haiman, C;Heavner, BD;Hidalgo, B;Hixson, JE;Ho, YL;Hobbs, BD;Hu, D;Hui, Q;Hwu, CM;Jackson, RD;Jain, D;Kalyani, RR;Kardia, SLR;Kelly, TN;Lange, EM;LeNoir, M;Li, C;Marchand, LL;McDonald, MN;McHugh, CP;Morrison, AC;Naseri, T;O'Connell, J;O'Donnell, CJ;Palmer, ND;Pankow, JS;Perry, JA;Peters, U;Preuss, MH;Rao, DC;Regan, EA;Reupena, SM;Roden, DM;Rodriguez-Santana, J;Sitlani, CM;Smith, JA;Tiwari, HK;Vasan, RS;Wang, Z;Weeks, DE;Wessel, J;Wiggins, KL;Wilkens, LR;Wilson, PWF;Yanek, LR;Yoneda, ZT;Zhao, W;Zöllner, S;Arnett, DK;Ashley-Koch, AE;Barnes, KC;Blangero, J;Boerwinkle, E;Burchard, EG;Carson, AP;Chasman, DI;Chen, YI;Curran, JE;Fornage, M;Gordeuk, VR;He, J;Heckbert, SR;Hou, L;Irvin, MR;Kooperberg, C;Minster, RL, .;et al.
    Contributors: Institute of Population Health Sciences
    Abstract: Obesity is a major public health crisis associated with high mortality rates. Previous genome-wide association studies (GWAS) investigating body mass index (BMI) have largely relied on imputed data from European individuals. This study leveraged whole-genome sequencing (WGS) data from 88,873 participants from the Trans-Omics for Precision Medicine (TOPMed) Program, of which 51% were of non-European population groups. We discovered 18 BMI-associated signals (P < 5 × 10(-9)). Notably, we identified and replicated a novel low frequency single nucleotide polymorphism (SNP) in MTMR3 that was common in individuals of African descent. Using a diverse study population, we further identified two novel secondary signals in known BMI loci and pinpointed two likely causal variants in the POC5 and DMD loci. Our work demonstrates the benefits of combining WGS and diverse cohorts in expanding current catalog of variants and genes confer risk for obesity, bringing us one step closer to personalized medicine.
    Date: 2023-08-22
    Relation: medRxiv. 2023 Aug 22;Article in Press.
    Link to: http://dx.doi.org/10.1101/2023.08.21.23293271
    Appears in Collections:[Yen-Feng Chiu] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    PUB37662265.pdf1066KbAdobe PDF68View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback