Introduction: Cognitive frailty (CF), coexistence of cognitive impairment and physical frailty, occurs frequently in geriatric population [1]. How much related between cognitive and frailty in middle-aged is less known to date. Methods: This study selected 287 subjects with average age 60 from the Healthy Aging Longitudinal Study in Taiwan (HALST) database, examined the collected variables in a subject from age 60 (wave 1) to age 66 (wave 2), and measured their peripheral blood C-C motif chemokine ligand 11 (CCL11, also called eotaxin-1), Insulin-like growth factor 1 (IGF-1) [2], and soluble form Tumor necrosis factor receptor 1 (TNFR1) [3]. The generalized estimating equations method (GEE) was used for the characteristics between two waves. The Bonferroni method was used to account for multiple testing and the false discovery rates (FDR) for the GEE p-values were calculated. Results: Compared to the baseline, after 6-year observation, people had decline in height, diastolic blood pressure, low-density lipoprotein (LDL) level, Mini-Mental State Examination (MMSE) score and increase in waistline. While there were significant increase in CCL11 and decrease in IGF-1 after 6 year, TNF-R1 level remained similar between two waves. Changes of total score of frailty (FS) between two waves was significantly and negatively associated with MMSE (β = -0.72, 95% CI -1.08 to -0.37, p <0.0001). Multiple-variable GEE showed that changes in FS was independently associated with that in MMSE (p = 0.0002). Changes in IGF-1 was significantly and positively associated with that in MMSE (p = 0.002) but not in FS, while changes inTNF-R1 was borderline positively associated with that in FS (p = 0.006) but not in MMSE. Conclusions: This study discovered cognitive frailty in middle aged healthy people. Increased blood IGF-1 level may be a predictor for MMSE preservation in middle aged people. Further investigation is rendered for examining whether blood TNF-R1 can be a predictor for occurrence of FS.
Date:
2023-07
Relation:
British Journal of Pharmacology. 2023 Jul;180(Suppl. 1):254.
