國家衛生研究院 NHRI:Item 3990099045/15359
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15359


    Title: Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
    Authors: Tobias, DK;Merino, J;Ahmad, A;Aiken, C;Benham, JL;Bodhini, D;Clark, AL;Colclough, K;Corcoy, R;Cromer, SJ;Duan, D;Felton, JL;Francis, EC;Gillard, P;Gingras, V;Gaillard, R;Haider, E;Hughes, A;Ikle, JM;Jacobsen, LM;Kahkoska, AR;Kettunen, JLT;Kreienkamp, RJ;Lim, L-L;Männistö, JME;Massey, R;McLennan, N-M;Miller, RG;Morieri, ML;Most, J;Naylor, RN;Ozkan, B;Patel, KA;Pilla, SJ;Prystupa, K;Raghavan, S;Rooney, MR;Schön, M;Semnani-Azad, Z;Sevilla-Gonzalez, M;Svalastoga, P;Takele, WW;Tam, CH-t;Thuesen, ACB;Tosur, M;Wallace, AS;Wang, CC;Wong, JJ;Yamamoto, JM;Young, K;Amouyal, C;Andersen, MK;Bonham, MP;Chen, M;Cheng, F;Chikowore, T;Chivers, SC;Clemmensen, C;Dabelea, D;Dawed, AY;Deutsch, AJ;Dickens, LT;DiMeglio, LA;Dudenhöffer-Pfeifer, M;Evans-Molina, C;Fernández-Balsells, MM;Fitipaldi, H;Fitzpatrick, SL;Gitelman, SE;Goodarzi, MO;Grieger, JA;Guasch-Ferré, M;Habibi, N;Hansen, T;Huang, C;Harris-Kawano, A;Ismail, HM;Hoag, B;Johnson, RK;Jones, AG;Koivula, RW;Leong, A;Leung, GKW;Libman, IM;Liu, K;Long, SA;Lowe, WL;Morton, RW;Motala, AA;Onengut-Gumuscu, S;Pankow, JS;Pathirana, M;Pazmino, S;Perez, D;Petrie, JR;Powe, CE;Quinteros, A;Jain, R;Ray, D;Ried-Larsen, M;Saeed, Z;Santhakumar, V;Kanbour, S;Sarkar, S;Monaco, GSF;Scholtens, DM;Selvin, E;Sheu, WH-H;Speake, C;Stanislawski, MA;Steenackers, N;Steck, AK;Stefan, N;Støy, J;Taylor, R;Tye, SC;Ukke, GG;Urazbayeva, M;Van der Schueren, B;Vatier, C;Wentworth, JM;Hannah, W;White, SL;Yu, G;Zhang, Y;Zhou, SJ;Beltrand, J;Polak, M;Aukrust, I;de Franco, E;Flanagan, SE;Maloney, KA;McGovern, A;Molnes, J;Nakabuye, M;Njølstad, PR;Pomares-Millan, H;Provenzano, M;Saint-Martin, C;Zhang, C;Zhu, Y;Auh, S;de Souza, R;Fawcett, AJ;Gruber, C;Mekonnen, EG;Mixter, E;Sherifali, D;Eckel, RH;Nolan, JJ;Philipson, LH;Brown, RJ;Billings, LK;Boyle, K;Costacou, T;Dennis, JM;Florez, JC;Gloyn, AL;Gomez, MF;Gottlieb, PA;Greeley, SAW;Griffin, K;Hattersley, AT;Hirsch, IB;Hivert, M-F;Hood, KK;Josefson, JL;Kwak, SH;Laffel, LM;Lim, SS;Loos, RJF;Ma, RCW;Mathieu, C;Mathioudakis, N;Meigs, JB;Misra, S;Mohan, V;Murphy, R;Oram, R;Owen, KR;Ozanne, SE;Pearson, ER;Perng, W;Pollin, TI;Pop-Busui, R;Pratley, RE;Redman, LM;Redondo, MJ;Reynolds, RM;Semple, RK;Sherr, JL;Sims, EK;Sweeting, A;Tuomi, T;Udler, MS;Vesco, KK;Vilsbøll, T;Wagner, R;Rich, SS;Franks, PW
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications. This second international consensus report on precision diabetes medicine summarizes the findings from a systematic evidence review across the key pillars of precision medicine (prevention, diagnosis, treatment, prognosis) in four recognized forms of diabetes (monogenic, gestational, type 1, type 2). These reviews address key questions about the translation of precision medicine research into practice. Although not complete, owing to the vast literature on this topic, they revealed opportunities for the immediate or near-term clinical implementation of precision diabetes medicine; furthermore, we expose important gaps in knowledge, focusing on the need to obtain new clinically relevant evidence. Gaps include the need for common standards for clinical readiness, including consideration of cost-effectiveness, health equity, predictive accuracy, liability and accessibility. Key milestones are outlined for the broad clinical implementation of precision diabetes medicine.
    Date: 2023-10-05
    Relation: Nature Medicine. 2023 Oct 05;29(10):2438-2457.
    Link to: https://doi.org/10.1038/s41591-023-02502-5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1546-170X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001085074500001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85173437266
    Appears in Collections:[Huey-Herng Sheu] Periodical Articles

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