國家衛生研究院 NHRI:Item 3990099045/15309
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    题名: Effect of limb salvage by excimer laser angioplasty plus low-pressure balloon inflation in chronic limb-threatening ischemia patients with infrapopliteal vessel disease
    作者: Yang, YP;Lin, TH;Chou, CY;Lee, CL;Huang, HK;Wu, XN;Chen, CP
    贡献者: Institute of Biomedical Engineering and Nanomedicine;NHRI Graduate Student Program
    摘要: BACKGROUND: Patients with chronic limb-threatening ischemia (CLTI) often exhibit long, diffuse, totally occluded and heavily calcified infrapopliteal (IP) lesions. This study evaluated limb salvage after peripheral excimer laser atherectomy (PELA) plus low-pressure balloon inflation (LPBI) without stent deployment in CLTI patients with severe IP disease. METHODS: We retrospectively evaluated 70 consecutive patients with 109 IP vessels who underwent PELA plus LPBI from 2010 to 2013. Technical success was defined as at least one IP straight-line flow being achieved below the malleolus. Binary logistic regression was performed to identify factors associated with 6-month limb salvage. RESULTS: Of the 109 IP vessels, 100 (91.7%) were totally occluded, and none of the patients received a stent. Of the 70 patients, 20% were octogenarians, and 85.8% had a Rutherford-Becker class 5 and 6. The technical success rate was 87.1% and 6-month limb salvage rate was 78.6%. Rutherford score was negatively correlated with clinical success (adjusted odds ratio 0.24; p = 0.028). No immediate major cardiovascular events were recorded during admission. CONCLUSIONS: PELA plus LPBI may be a treatment option for complex IP lesions in patients with CLTI. Higher Rutherford class was correlated with a lower 6-month limb salvage rate. However, a large-scale study with a control group is needed to clarify our results.
    日期: 2023-09
    關聯: Acta Cardiologica Sinica. 2023 Sep;39(5):765-772.
    Link to: http://dx.doi.org/10.6515/acs.202309_39(5).20230115a
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1011-6842&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001108831500005
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85172287079
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