國家衛生研究院 NHRI:Item 3990099045/15289

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15289

Title:	Rest-activity rhythm associated with depressive symptom severity and attention among patients with major depressive disorder: A 12-month follow-up study
Authors:	Yang, HJ;Cheng, WJ;Hsiao, MC;Huang, SC;Kubo, T;Hang, LW;Lee, WS
Contributors:	National Center for Geriatrics and Welfare Research
Abstract:	Introduction Patients with depressive disorder demonstrate rest-activity rhythm disturbances and cognitive function impairment. This study examined the association of individual rest-activity rhythm changes over time with mood symptoms and attention.Methods We recruited 15 adult outpatients with a diagnosis of major depressive disorder from a single medical center and observed them for 12 months. Weekly rest-activity parameters, including rhythm characteristics generated from nonparametric circadian rhythm analysis, were retrieved from actigraphy data. Attention was evaluated weekly with a smartphone-based psychomotor vigilance test upon awakening. Depressive symptom severity was evaluated using the Beck Depression Inventory (BDI) fortnightly. The association of rest-activity parameters with BDI score and attention was examined using generalized linear mixed regression. A fixed-effects analysis was used to examine the association between rest-activity parameters and depressive episodes.Results An advanced bedtime and most active continuous 10 h starting time were associated with depressive symptom severity but also associated with higher vigilance test performance. A longer sleep duration, mainly due to an earlier bedtime, was associated with depressive symptom severity. Compared to remission, sleep duration was 27.8 min longer during depressive episodes, and bed time was 24 min earlier. A shorter sleep duration and increased activity during sleep were associated with poorer attention.Discussion Rest-activity rhythms change with mood symptoms among patients with depressive disorder. The circadian rhythms of rest-activity among patients with depressive disorder should be distinguished during various mood states in future studies.
Date:	2023-08-10
Relation:	Frontiers in Psychiatry. 2023 Aug 10;14:Article number 1214143.
Link to:	http://dx.doi.org/10.3389/fpsyt.2023.1214143
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-0640&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001058664500001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85169536801
Appears in Collections:	[Wan-Ju Cheng] Periodical Articles

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