國家衛生研究院 NHRI:Item 3990099045/1526
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1526


    Title: A reevaluation and discussion on the threshold limit for hemolysis in a turbulent shear flow
    Authors: Lu, PC;Lai, HC;Liu, JS
    Contributors: Division of Medical Engineering Research
    Abstract: One major factor of red blood cell damage induced by artificial heart valves is the magnitude of turbulent shear stresses in the flow field. An often-cited threshold for hemolysis is 400 N/m(2) (Sallam and Hwang, Biorheology 21 (1984) 783). This value, however, was measured with a one-component laser Doppler anemometer and was not calculated from the major principal Reynolds shear stress, therefore underestimatng the threshold. This study performed flow field measurements under similar conditions, using a two-component laser Doppler anemometer and determining major principal Reynolds shear stress. to reevaluate the hemolytic threshold as 800 N/m(2) with an exposure time of 1 ms. The Kolmogorov length scales. approximately 9 mum. are capable of inflicting direct damage to the red blood cells. These results will serve as a more accurate reference in future heart valve design and testing. (C) 2001 Elsevier Science Ltd. All rights reserved.
    Keywords: Biophysics;Engineering, Biomedical
    Date: 2001-10
    Relation: Journal of Biomechanics. 2001 Oct;34(10):1361-1364.
    Link to: http://dx.doi.org/10.1016/S0021-9290(01)00084-7
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-9290&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000170925600015
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034879360
    Appears in Collections:[Others] Periodical Articles

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