國家衛生研究院 NHRI:Item 3990099045/15243
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    题名: Sequence-specific targeting of C. elegans C-Ala to the D-loop of tRNA(Ala)
    作者: Antika, TR;Nazilah, KR;Chrestella, DJ;Wang, TL;Tseng, YK;Wang, SC;Hsu, HL;Wang, SW;Chuang, TH;Pan, HC;Horng, JC;Wang, CC
    贡献者: Institute of Molecular and Genomic Medicine;Immunology Research Center
    摘要: Alanyl-tRNA synthetase (AlaRS) retains a conserved prototype structure throughout its biology. Nevertheless, its C-terminal domain (C-Ala) is highly diverged and has been shown to play a role in either tRNA or DNA binding. Interestingly, we discovered that Caenorhabditis elegans cytoplasmic C-Ala (Ce-C-Ala(c)) robustly binds both ligands. How Ce-C-Ala(c) targets its cognate tRNA and whether a similar feature is conserved in its mitochondrial counterpart remain elusive. We show that the N- and C-terminal subdomains of Ce-C-Ala(c) are responsible for DNA and tRNA binding, respectively. Ce-C-Ala(c) specifically recognized the conserved invariant base G(18) in the D-loop of tRNA(Ala) through a highly conserved lysine residue, K934. Despite bearing little resemblance to other C-Ala domains, C. elegans mitochondrial C-Ala (Ce-C-Ala(m)) robustly bound both tRNA(Ala) and DNA and maintained targeting specificity for the D-loop of its cognate tRNA. This study uncovers the underlying mechanism of how C. elegans C-Ala specifically targets the D-loop of tRNA(Ala).
    日期: 2023-08-09
    關聯: Journal of Biological Chemistry. 2023 Aug 9;299-302(9):Article number 105149.
    Link to: http://dx.doi.org/10.1016/j.jbc.2023.105149
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1083-351X&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85169502826
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