國家衛生研究院 NHRI:Item 3990099045/1522
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    题名: Quantitative evaluation of the use of microbubbles with transcranial focused ultrasound on blood-brain-barrier disruption
    作者: Yang, FY;Fu, WM;Chen, WS;Yeh, WL;Lin, WL
    贡献者: Division of Medical Engineering Research
    摘要: It has been shown that focused ultrasound (FUS) can disrupt the blood-brain barrier (BBB) noninvasively and reversibly at target locations when applied in the presence of ultrasound contrast agent (UCA). In this study, the dose-dependent effects of UCA on BBB disruption were investigated in the brains of 16 male Wistar rats sonicated by 1.0-MHz transcranial FUS, with the UCA present at four doses. The BBB disruption was evaluated quantitatively based on the extravasation of Evans blue (EB). The amount of EB extravasation in the brain increased with the quantity of UCA injected into the femoral vein prior to sonication. Moreover, the use of a suitable dose of UCA resulted in the BBB disruption being concentrated in the focal region instead of the entire brain. Our results indicate that injecting an appropriate quantity of UCA effectively increases and localizes the BBB disruption induced by transcranial FUS sonications. (c) 2007 Elsevier B.V. All rights reserved.
    关键词: Acoustics;Chemistry, Multidisciplinary
    日期: 2008-04
    關聯: Ultrasonics Sonochemistry. 2008 Apr;15(4):636-643.
    Link to: http://dx.doi.org/10.1016/j.ultsonch.2007.08.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1350-4177&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000254443900056
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=44249098561
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