國家衛生研究院 NHRI:Item 3990099045/15212
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    题名: Mechanical transmission of dengue virus by Aedes aegypti may influence disease transmission dynamics during outbreaks
    作者: Li, HH;Su, MP;Wu, SC;Tsou, HH;Chang, MC;Cheng, YC;Tsai, KN;Wang, HW;Chen, GH;Tang, CK;Chung, PJ;Tsai, WT;Huang, LR;Yueh, YA;Chen, HW;Pan, CY;Akbari, OS;Chang, HH;Yu, GY;Marshall, JM;Chen, CH
    贡献者: National Mosquito-Borne Diseases Control Research Center;National Institute of Infectious Diseases and Vaccinology;Institute of Population Health Sciences;Institute of Biotechnology and Pharmaceutical Research;Institute of Molecular and Genomic Medici
    摘要: Background: Dengue virus outbreaks are increasing in number and severity worldwide. Viral transmission is assumed to require a minimum time period of viral replication within the mosquito midgut. It is unknown if alternative transmission periods not requiring replication are possible. Methods: We used a mouse model of dengue virus transmission to investigate the potential of mechanical transmission of dengue virus. We investigated minimal viral titres necessary for development of symptoms in bitten mice and used resulting parameters to inform a new model of dengue virus transmission within a susceptible population. Findings: Naïve mice bitten by mosquitoes immediately after they took partial blood meals from dengue infected mice showed symptoms of dengue virus, followed by mortality. Incorporation of mechanical transmission into mathematical models of dengue virus transmission suggest that this supplemental transmission route could result in larger outbreaks which peak sooner. Interpretation: The potential of dengue transmission routes independent of midgut viral replication has implications for vector control strategies that target mosquito lifespan and suggest the possibility of similar mechanical transmission routes in other disease-carrying mosquitoes. Funding: This study was funded by grants from the National Health Research Institutes, Taiwan (04D2-MMMOST02), the Human Frontier Science Program (RGP0033/2021), the National Institutes of Health (1R01AI143698-01A1, R01AI151004 and DP2AI152071) and the Ministry of Science and Technology, Taiwan (MOST104-2321-B-400-016).
    日期: 2023-08
    關聯: eBioMedicine. 2023 Aug;Article number 104723.
    Link to: http://dx.doi.org/10.1016/j.ebiom.2023.104723
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2352-3964&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=8516559645
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