國家衛生研究院 NHRI:Item 3990099045/15075
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    题名: Recombinant lipidated FLIPr effectively enhances mucosal and systemic immune responses for various vaccine types
    作者: Hsieh, MS;Chen, MY;Hsu, CW;Tsai, YW;Chiu, FF;Hsu, CL;Lin, CL;Wu, CC;Tu, LL;Chiang, CY;Liu, SJ;Liao, CL;Chen, HW
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Formyl peptide receptor-like 1 inhibitor protein (FLIPr) is an immune evasion protein produced by Staphylococcus aureus, and FLIPr is a potential vaccine candidate for reducing Staphylococcus aureus virulence and biofilm formation. We produced recombinant lipidated FLIPr (rLF) to increase the immunogenicity of FLIPr and showed that rLF alone elicited potent anti-FLIPr antibody responses to overcome the FLIPr-mediated inhibition of phagocytosis. In addition, rLF has potent immunostimulatory properties. We demonstrated that rLF is an effective adjuvant. When an antigen is formulated with rLF, it can induce long-lasting antigen-specific immune responses and enhance mucosal and systemic antibody responses as well as broad-spectrum T-cell responses in mice. These findings support further exploration of rLF in the clinic as an adjuvant for various vaccine types with extra benefits to abolish FLIPr-mediated immunosuppressive effects.
    日期: 2023-06-02
    關聯: npj Vaccines. 2023 Jun 02;8:Article number 82.
    Link to: http://dx.doi.org/10.1038/s41541-023-00680-4
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2059-0105&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000999859200002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85160925840
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