國家衛生研究院 NHRI:Item 3990099045/15010
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15010


    Title: A nationwide study of prenatal exposure to illicit drugs and risk of neurodevelopmental disorders and disruptive behavioral disorders
    Authors: Lin, CH;Chen, MH;Lin, WS;Wu, SI;Liao, YC;Lin, YH
    Contributors: Institute of Population Health Sciences
    Abstract: This cohort study aimed to examine the association between prenatal exposure to illicit drugs and neurodevelopmental and disruptive behavioral disorders (DBD) in children aged 7–12 years, using data from four national databases in Taiwan from 2004 to 2016. We linked parental and child IDs from the Taiwan Maternal and Child Health database to track children's health status from birth to at least age 7 and identify those diagnosed with neurodevelopmental disorders. The study included 896,474 primiparous women who gave birth between 2004 and 2009, with 752 pregnant women with illicit drug use history and 7520 matched women without. The results of the study showed that prenatal illicit drug exposure was significantly associated with the development of neurodevelopmental disorders and DBD in offspring. The adjusted hazard ratios for developmental delay, mild-to-severe intellectual disability, attention deficit hyperactivity disorder, and DBD were 1.54 (95 % CI: 1.21–1.95), 2.63 (95 % CI: 1.64–4.19), 1.58 (95 % CI: 1.23–2.03), and 2.57 (95 % CI: 1.21–5.48), respectively. Furthermore, prenatal exposure to methamphetamine increased the risk of neurodevelopmental disorders and DBD in offspring, while opioid use was significantly associated with a higher risk of three types of neurodevelopmental disorders, but not with DBD. The use of sedative hypnotic drugs alone was not associated with any increased risk of the three types of neurodevelopmental disorders or DBD. However, we found a significant interaction effect between prenatal illicit drug exposure and the use of sedative hypnotic drugs, which increased the risk of developmental delay.
    Date: 2023-07
    Relation: Asian Journal of Psychiatry. 2023 Jul;85:Article number 103597.
    Link to: http://dx.doi.org/10.1016/j.ajp.2023.103597
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1876-2018&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000992828400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85154037896
    Appears in Collections:[Yu-Hsuan Lin] Periodical Articles
    [Shiow-Ing Wu] Periodical Articles

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