國家衛生研究院 NHRI:Item 3990099045/15008
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    题名: Revisiting the effects of exercise on cerebral neurovascular functions in rats using multimodal assessment techniques
    作者: Yen, S;Wu, HY;Wang, Y;Huang, CM;Wu, CW;Chen, JH;Liao, LD
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Physical activity in the form of aerobic exercise has many beneficial effects on brain function. Here, we aim to revisit the effects of exercise on brain morphology and neurovascular organization using a rat running model. Electrocorticography (ECoG) was integrated with laser speckle contrast imaging (LSCI) and applied to simultaneously detect CSD propagation and the corresponding neurovascular function. In addition, blood oxygenation level–dependent (BOLD) signal in fMRI was used to observe cerebral utilization of oxygen. Results showed significant decrease in somatosensory evoked potentials (SSEPs) and deceleration of CSD propagation in the EXE group. Western blot results in the EXE group showed significant increases in BDNF, GFAP, and NeuN levels and significant decreases in neurodegenerative disease markers. Decreases in SSEP and CSD parameters may result from exercise-induced increases in cerebrovascular system function and increases in the stability and buffering of extracellular ion concentrations and cortical excitability.
    日期: 2023-04-21
    關聯: iScience. 2023 Apr 21;26(4):Article number 106354.
    Link to: http://dx.doi.org/10.1016/j.isci.2023.106354
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2589-0042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000996476600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85151433388
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