國家衛生研究院 NHRI:Item 3990099045/15007
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    题名: Real-time observation for dynamic oscillation during the self-assembly and clearance of Abeta42
    其它题名: Real-time observation for dynamic oscillation during the self-assembly and clearance of Aβ42
    作者: Yao, CN;Wu, TH;Cheng, PY;Tsao, YC;Lu, YF;Chu, LK;Chiu, CC;Lin, SY
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: The dynamic oscillation implicated in structural heterogeneity during the self-assembly of amyloid peptide 1-42 (Aβ42) may play a crucial role in eliciting cellular responses. We developed a real-time monitoring platform to observe an oscillatory non-equilibrium interaction that dominated the Aβ42 clearance by neuronal cells during interplay with an oscillator (lipopolysaccharide, LPS). Molecular dynamics studies indicated that the electrostatic and hydrophobic segments of LPS involved in the temporary heteromolecular association and slightly decelerated the intrinsic thermally-induced protein dynamics of Aβ42. A bait-specific intervention strategy could temporarily slow down the self-propagation of Aβ42 to extend the lifetime of autonomous oscillation and augment the Aβ42 clearance of neuronal cells. The lifetime increment of dynamic oscillation shows a bait concentration-dependent manner to reflect the non-equilibrium binding strength. This relationship may serve as a drug-screening predictor for Alzheimer's disease drug discovery.
    日期: 2023-06
    關聯: Chemistry-A European Journal. 2023 Jun 22;29(35):Article number e202300142.
    Link to: http://dx.doi.org/10.1002/chem.202300142
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0947-6539&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000985020000001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85158143833
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