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显示项目1-50 / 66. (共2页) 1 2 > >> 每页显示[10|25|50]项目

日期	题名	關聯
2021-08-12	Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2)	Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
2021-08-01	DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity	Life Sciences. 2021 Aug 1;278:Article number 119574.
2021-01	Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease	European Journal of Medicinal Chemistry. 2021 Jan;209:Article number 112938.
2019-12	Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia	Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
2019-07	Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216	Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 4626.
2019-05-28	Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform	Cancers. 2019 May 28;11(6):Article number 739.
2019-04-10	Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants	Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
2018-08-24	BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor	Cancer Science. 2018 Nov;109(11):3591-3601.
2016-12	Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST	Annals of Oncology. 2016 Dec;27(Suppl. 9):Meeting Abstract 2P.
2016-10	BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia	Molecular Cancer Therapeutics. 2016 Oct;15(10):2323-2333.
2016-04-12	Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK)	Journal of Medicinal Chemistry. 2016 Apr 12;59(8):3906-3919.
2015-07	Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations	European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
2014-08-01	Pyrrolidine derivatives	特許第5,586,484號/2014-08-01
2014-05-12	Pyrrolidine derivatives	J001349/2014-05-12
2014-05-08	Pyrrolidine derivatives	AU2009222198/2014-05-08
2014-04-25	Pyrrolidine derivatives	HK1149261/2014-04-25
2014-04-21	作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途	I434834/2014-04-21
2014-02-19	Pyrrolidine derivatives	EP2252582/2014-02-19
2014-02	Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation	PLoS ONE. 2014 Feb 13;9(2):Article number e88772.
2014-01-08	Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer	PLoS ONE. 2014 Jan 8;9(1):Article number e83160.
2014-01	A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease	Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119.
2013-12-18	吡咯烷化合物	ZL200980107941.2/2013-12-18
2013-09-27	Pyrrolidine derivatives	RU2494094C2/2013-09-27
2013-06-28	Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor	Journal of Medicinal Chemistry. 2013 Jun 28;56(13):5247-5260.
2013-06	Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867.
2013-04-30	Pyrrolidine derivatives	164613/2013-04-30
2013-02-11	吡咯啉啶化合物	I385163/2013-02-11
2013-02-11	吡咯啶化合物	I385171/2013-02-11
2013-02	Resistance studies of a di-thiazol analogue, DBPR110, as a potential hepatitis C virus NS5A inhibitor in replicon systems	Antimicrobial Agents and Chemotherapy. 2013 Feb; 57(2):723-733.
2012-11	BPR1J271, a novel FLT3 inhibitor for treating acute myeloid leukemia	European Journal of Cancer. 2012 Nov;48(Suppl. 6):53-54.
2012-06-15	Pyrrolidine derivatives	587911/2012-06-15
2012-06-07	3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	Bioorganic and Medicinal Chemistry Letters. 2012 Jun 7;22(14):4654-4659.
2012-04-21	吡咯啉啶化合物	I362388/2012-04-21
2012-01-17	Pyrrolidine compounds	CA2559611/2012-01-17
2012-01	Resistance analysis and characterization of a thiazole analogue, BP008, as a potent hepatitis C virus NS5A inhibitor	Antimicrobial Agents and Chemotherapy. 2012 Jan;56(1):44-53.
2012-01	BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML	British Journal of Cancer. 2012 Jan;106(3):475-481.
2011-12-06	Pyrrolidine compounds	US8071787B2/2011-12-06
2011-09-20	Pyrrolidine derivatives	US8022096B2/2011-09-20.
2011-07	Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3)	Bioorganic and Medicinal Chemistry. 2011 Jul;19(14):4173-4182 .
2011-06	Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate	Journal of Biochemistry. 2011 Jun;149(6):685-692.
2011-06	Current advances and therapeutic potential of agents targeting dipeptidyl peptidases-IV, -II, 8/9 and fibroblast activation protein	Current Topics In Medicinal Chemistry. 2011 Jun;(11):1447-1463.
2011-05-25	Pyrrolidine derivatives	ZA201006329B/2011-05-25
2011-02	Synthesis of 3,3-dimethylglutamic acid derivatives as DPP-IV inhibitors and evaluation of their chemical stability	Journal of the Chinese Chemical Society. 2011 Feb;58(1):108-117.
2010-10-06	吡咯烷化合物	ZL200580009891.6/2010-10-06
2010-09	The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities	Protein Science. 2010 Sep;19(9):1627-1638.
2010-08	Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein	Journal of Medicinal Chemistry. 2010 Aug;53(18):6572-6583.
2010-06-15	(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV	Bioorganic and Medicinal Chemistry Letters. 2010 Jun 15;20(12):3596-3600.
2010-03-30	Pyrrolidine compounds	US7687504B2/2010-03-30
2009-10	(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine analogues as inhibitors of dipeptidyl peptidases	Journal of the Chinese Chemical Society. 2009 Oct;56(5):1048-1055.
2009-07-15	Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor	Biochemical Pharmacology. 2009 Jul 15;78(2):203-210.

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