國家衛生研究院 NHRI:
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    日期題名關聯
    2021-08-12 Xanthine derivatives reveal an allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) Journal of Medicinal Chemistry. 2021 Aug 12;64(15):11288-11301.
    2021-08-01 DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity Life Sciences. 2021 Aug 1;278:Article number 119574.
    2021-01 Potent and orally active purine-based fetal hemoglobin inducers for treating Beta-thalassemia and sickle cell disease European Journal of Medicinal Chemistry. 2021 Jan;209:Article number 112938.
    2019-12 Identification of a multitargeted tyrosine kinase inhibitor for the treatment of gastrointestinal stromal tumors and acute myeloid leukemia Journal of Medicinal Chemistry. 2019 Dec;62(24):11135-11150.
    2019-07 Use of integrated genomic analyses in patient-derived tumor model to discover new clinical indications for the multikinase inhibitor drug candidate, DBPR216 Cancer Research. 2019 Jul;79(13, Suppl.):Abstract number 4626.
    2019-05-28 Identification of novel anti-liver cancer small molecules with better therapeutic index than sorafenib via zebrafish drug screening platform Cancers. 2019 May 28;11(6):Article number 739.
    2019-04-10 Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants Journal of Medicinal Chemistry. 2019 Apr 10;62(8):3940-3957.
    2018-08-24 BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor Cancer Science. 2018 Nov;109(11):3591-3601.
    2016-12 Novel cKIT kinase inhibitor, BPRCKJ001, as an advanced therapeutic candidate for GIST Annals of Oncology. 2016 Dec;27(Suppl. 9):Meeting Abstract 2P.
    2016-10 BPR1J373, an oral multiple tyrosine kinase inhibitor, targets c-KIT for the treatment of c-KIT driven myeloid leukemia Molecular Cancer Therapeutics. 2016 Oct;15(10):2323-2333.
    2016-04-12 Pyrazolylamine derivatives reveal the conformational switching between type I and type II binding modes of Anaplastic Lymphoma Kinase (ALK) Journal of Medicinal Chemistry. 2016 Apr 12;59(8):3906-3919.
    2015-07 Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations European Journal of Medicinal Chemistry. 2015 Jul;100:151-161.
    2014-08-01 Pyrrolidine derivatives 特許第5,586,484號/2014-08-01
    2014-05-12 Pyrrolidine derivatives J001349/2014-05-12
    2014-05-08 Pyrrolidine derivatives AU2009222198/2014-05-08
    2014-04-25 Pyrrolidine derivatives HK1149261/2014-04-25
    2014-04-21 作為蛋白質激酶抑制劑之吡唑化合物及噻唑化合物、其醫藥組成物及用途 I434834/2014-04-21
    2014-02-19 Pyrrolidine derivatives EP2252582/2014-02-19
    2014-02 Fibroblast activation protein (FAP) is essential for the migration of bone marrow mesenchymal stem cells through RhoA activation PLoS ONE. 2014 Feb 13;9(2):Article number e88772.
    2014-01-08 Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer PLoS ONE. 2014 Jan 8;9(1):Article number e83160.
    2014-01 A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease Antimicrobial Agents and Chemotherapy. 2014 Jan;58(1):110-119.
    2013-12-18 吡咯烷化合物 ZL200980107941.2/2013-12-18
    2013-09-27 Pyrrolidine derivatives RU2494094C2/2013-09-27
    2013-06-28 Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine aurora kinase inhibitor Journal of Medicinal Chemistry. 2013 Jun 28;56(13):5247-5260.
    2013-06 Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3) Bioorganic and Medicinal Chemistry. 2013 Jun;21(11):2856-2867.

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