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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/14976
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| Title: | Subunit vaccines with a saponin-based adjuvant boost humoral and cellular immunity to MERS coronavirus |
| Authors: | Chang, CC;Algaissi, A;Lai, CC;Chang, CK;Lin, JS;Wang, YS;Chang, BH;Chang, YC;Chen, WT;Fan, YQ;Peng, BH;Chao, CY;Tzeng, SR;Liang, PH;Sung, WC;Hu, AY;Chang, SC;Chang, MF |
| Contributors: | National Institute of Infectious Diseases and Vaccinology |
| Abstract: | Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks have constituted a public health issue with drastic mortality higher than 34%, necessitating the development of an effective vaccine. During MERS-CoV infection, the trimeric spike protein on the viral envelope is primarily responsible for attachment to host cellular receptor, dipeptidyl peptidase 4 (DPP4). With the goal of generating a protein-based prophylactic, we designed a subunit vaccine comprising the recombinant S1 protein with a trimerization motif (S1-Fd) and examined its immunogenicity and protective immune responses in combination with various adjuvants. We found that sera from immunized wild-type and human DPP4 transgenic mice contained S1-specific antibodies that can neutralize MERS-CoV infection in susceptible cells. Vaccination with S1-Fd protein in combination with a saponin-based QS-21 adjuvant provided long-term humoral as well as cellular immunity in mice. Our findings highlight the significance of the trimeric S1 protein in the development of MERS-CoV vaccines and offer a suitable adjuvant, QS-21, to induce robust and prolonged memory T cell response. |
| Date: | 2023-04-10 |
| Relation: | Vaccine. 2023 Apr 10;41(21):3337-3346. |
| Link to: | http://dx.doi.org/10.1016/j.vaccine.2023.04.006 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0264-410X&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001001263600001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85153030696 |
| Appears in Collections: | [宋旺洲] 期刊論文
[胡勇誌] 期刊論文
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| PUB37085450.pdf | | 2375Kb | Adobe PDF | 220 | View/Open |
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