國家衛生研究院 NHRI:Item 3990099045/14939
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 852101      在线人数 : 1343
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/14939


    题名: Genetics of antidepressant response and treatment-resistant depression
    作者: Chung, AN;Chen, TT;Lin, YF
    贡献者: Center for Neuropsychiatric Research
    摘要: Antidepressant response, the effectiveness of antidepressants in relieving symptoms of depression, is a complex trait influenced by both genetic and environmental factors. However, despite decades of research, the specific genetic variations that contribute to antidepressant response and treatment-resistant depression (TRD) remain largely unknown. In this review, we summarize the current state of knowledge of the genetics of antidepressant response and TRD, including candidate gene association studies, genome-wide association studies (GWAS), polygenic risk score (PRS) analyses, whole genome sequencing studies, research on other genetic and epigenetic changes, and the potential for precision medicine in this field. Although some progress has been made in identifying genetic factors associated with antidepressant response and TRD, much work remains to be done, particularly in terms of larger sample sizes and standardization of outcome measures. Further research in this area has the potential to improve the treatment of depression and increase the chances of successful treatment for individuals with this common and debilitating mental illness.
    日期: 2023-03-02
    關聯: Progress in Brain Research. 2023 Mar 2;278:25-60.
    Link to: http://dx.doi.org/10.1016/bs.pbr.2023.01.002
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85149736540
    显示于类别:[林彥鋒] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    SCP85149736540.pdf465KbAdobe PDF160检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈