國家衛生研究院 NHRI:Item 3990099045/14836
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    题名: Experimental verification for numerical simulation of thalamic stimulation-evoked calcium-sensitive fluorescence and electrophysiology with self-assembled multifunctional optrode
    作者: Liang, YW;Lai, ML;Chiu, FM;Tseng, HY;Lo, YC;Li, SJ;Chang, CW;Chen, PC;Chen, YY
    贡献者: NHRI Graduate Student Program
    摘要: Owing to its capacity to eliminate a long-standing methodological limitation, fiber photometry can assist research gaining novel insight into neural systems. Fiber photometry can reveal artifact-free neural activity under deep brain stimulation (DBS). Although evoking neural potential with DBS is an effective method for mediating neural activity and neural function, the relationship between DBS-evoked neural Ca(2+) change and DBS-evoked neural electrophysiology remains unknown. Therefore, in this study, a self-assembled optrode was demonstrated as a DBS stimulator and an optical biosensor capable of concurrently recording Ca(2+) fluorescence and electrophysiological signals. Before the in vivo experiment, the volume of tissue activated (VTA) was estimated, and the simulated Ca(2+) signals were presented using Monte Carlo (MC) simulation to approach the realistic in vivo environment. When VTA and the simulated Ca(2+) signals were combined, the distribution of simulated Ca(2+) fluorescence signals matched the VTA region. In addition, the in vivo experiment revealed a correlation between the local field potential (LFP) and the Ca(2+) fluorescence signal in the evoked region, revealing the relationship between electrophysiology and the performance of neural Ca(2+) concentration behavior. Concurrent with the VTA volume, simulated Ca(2+) intensity, and the in vivo experiment, these data suggested that the behavior of neural electrophysiology was consistent with the phenomenon of Ca(2+) influx to neurons.
    日期: 2023-02-13
    關聯: Biosensors. 2023 Feb 13;13(2):Article number 265.
    Link to: http://dx.doi.org/10.3390/bios13020265
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2079-6374&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000938463300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85148964646
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