國家衛生研究院 NHRI:Item 3990099045/14761

NHRI > National Institute of Infectious Diseases and Vaccinology > Guann-Yi Yu > Periodical Articles > Item 3990099045/14761

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14761

Title:	IFN-stimulated metabolite transporter ENT3 facilitates viral genome release
Authors:	Hsieh, YT;Tsai, TL;Huang, SY;Heng, JW;Huang, YC;Tsai, PY;Tu, CC;Chao, TL;Tsai, YM;Chang, PC;Lee, CK;Yu, GY;Chang, SY;Dzhagalov, IL;Hsu, CL
Contributors:	National Institute of Infectious Diseases and Vaccinology
Abstract:	An increasing amount of evidence emphasizes the role of metabolic reprogramming in immune cells to fight infections. However, little is known about the regulation of metabolite transporters that facilitate and support metabolic demands. In this study, we found that the expression of equilibrative nucleoside transporter 3 (ENT3, encoded by solute carrier family 29 member 3, Slc29a3) is part of the innate immune response, which is rapidly upregulated upon pathogen invasion. The transcription of Slc29a3 is directly regulated by type I interferon-induced signaling, demonstrating that this metabolite transporter is an interferon-stimulated gene (ISG). Suprisingly, we unveil that several viruses, including SARS-CoV-2, require ENT3 to facilitate their entry into the cytoplasm. The removal or suppression of Slc29a3 expression is sufficient to significantly decrease viral replication in vitro and in vivo. Our study reveals that ENT3 is a pro-viral ISG co-opted by some viruses to gain a survival advantage.
Date:	2023-03-06
Relation:	EMBO Reports. 2023 Mar 6;24(3):Article number e55286.
Link to:	http://dx.doi.org/10.15252/embr.202255286
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1469-221X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000950202800001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85146455320
Appears in Collections:	[Guann-Yi Yu] Periodical Articles

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