國家衛生研究院 NHRI:Item 3990099045/14732

NHRI > National Institute of Cancer Research > Li-Tzong Chen > Conference Papers/Meeting Abstract > Item 3990099045/14732

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14732

Title:	Outcomes of post-immunotherapy durable responders of advanced hepatocellular carcinoma - with emphasis on locoregional therapy for oligoprogression
Authors:	Liu, TH;Chen, SC;Rau, KM;Lu, LC;Lin, PT;Su, YY;Teng, W;Lai, SW;Yehn, RH;Kao, TM;Lee, PC;Wu, CJ;Chen, CH;Hsu, CH;Lin, SM;Huang, YH;Chen, LT;Cheng, AL;Shen, YC
Contributors:	National Institute of Cancer Research
Abstract:	Background: Increasingly more patients with ad-vanced hepatocellular carcinoma (HCC) achieve du-rable response (DR) with immune checkpoint inhibitor (ICI)-based immunotherapy. The objective of this study is to characterize the progression patterns, dispositions, and outcomes of a large group of real-world durable responders. Methods: This is a retrospective analysis involving 8 major referral medical centers in Taiwan. Patients with advanced HCC who received ICI-based immunotherapy and achieved DR were included for anal-ysis. DR was defined as partial response (PR) or stable disease (SD) per RECIST1.1 for more than 8 months after initiation of immunotherapy. Oligoprogression and polyprogression were defined as progression at ≤3 and >3 lesions, respectively. Locoregional therapy (LRT) herein included surgery, ablation, transarterial chemoembolization, yttrium-90 radioembolization, ra-diotherapy, and hepatic arterial infusion chemotherapy. Overall survival (OS) was defined as the time from the initiation of immunotherapy to death of any causes. Results: From August 2015 to March 2021, 91 durable responders (63 PR and 28 SD) were identified. Median age was 62.0 years. Most of them were male (n=69, 75.8%) and with chronic viral hepatitis (n=69, 75.8%).
Date:	2022-10
Relation:	Hepatology. 2022 Oct;76(Suppl.1):S1411-S1412.
Link to:	https://doi.org/10.1002/hep.32697
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0270-9139&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000870796604274
Appears in Collections:	[Li-Tzong Chen] Conference Papers/Meeting Abstract [Yung-Yeh Su] Conference Papers/Meeting Abstract

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