國家衛生研究院 NHRI:Item 3990099045/14728
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14728


    Title: Dihydromyricetin inhibited migration and invasion by reducing S100A4 expression through ERK1/2/beta-catenin pathway in human cervical cancer cell lines
    Other Titles: Dihydromyricetin inhibited migration and invasion by reducing S100A4 expression through ERK1/2/β-catenin pathway in human cervical cancer cell lines
    Authors: Hsin, MC;Hsiao, YH;Chen, PN;Lin, CW;Wang, PH;Yang, SF;Lee, CY
    Contributors: National Institute of Cancer Research
    Abstract: Cervical cancer has a poor prognosis and is the fourth most common cancer among women. Dihydromyricetin (DHM), a flavonoid compound, exhibits several pharmacological activities, including anticancer effects; however, the effects of DHM on cervical cancer have received insufficient research attention. This study examined the antitumor activity and underlying mechanisms of DHM on human cervical cancer. Our results indicated that DHM inhibits migration and invasion in HeLa and SiHa cell lines. Mechanistically, RNA sequencing analysis revealed that DHM suppressed S100A4 mRNA expression in HeLa cells. Moreover, DHM inhibited the protein expressions of beta-catenin and GSK3 beta through the regulated extracellular-signal-regulated kinase (ERK)1/2 signaling pathway. By using the ERK1/2 activator, T-BHQ, reverted beta-catenin and S100A4 protein expression and cell migration, which were reduced in response to DHM. In conclusion, our study indicated that DHM inhibited cell migration by reducing the S100A4 expression through the ERK1/2/beta-catenin pathway in human cervical cancer cell lines.
    Date: 2022-12-01
    Relation: International Journal of Molecular Sciences. 2022 Dec 1;23(23):Article number 15106.
    Link to: http://dx.doi.org/10.3390/ijms232315106
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000896911700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85143679508
    Appears in Collections:[Others] Periodical Articles

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