國家衛生研究院 NHRI:Item 3990099045/14726

NHRI > National Institute of Environmental Health Sciences > Shau-Ku Huang > Periodical Articles > Item 3990099045/14726

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Title:	Association of serum CC16 levels with eosinophilic inflammation and respiratory dysfunction in severe asthma
Authors:	Goudarzi, H;Kimura, H;Kimura, H;Makita, H;Takimoto-Sato, M;Abe, Y;Oguma, A;Matsumoto, M;Takei, N;Matsumoto-Sasaki, M;Shimizu, K;Suzuki, M;Shijubo, N;Huang, SK;Hizawa, N;Nishimura, M;Konno, S
Contributors:	National Institute of Environmental Health Sciences
Abstract:	BACKGROUND: There are knowledge gaps in the potential role of Club cell 16-kDa secretory protein (CC16) in severe asthma phenotypes and type 2 inflammation, as well as the longitudinal effect of CC16 on pulmonary function tests and exacerbation risk in epidemiological studies. OBJECTIVE AND METHODS: To assess whether serum CC16 is associated with eosinophilic inflammation in patients with severe asthma. We also examined the effect of this protein on the annual decline in forced expiratory volume in the first second (FEV(1)) and the risk of exacerbation using a longitudinal approach. We recruited 127 patients with severe asthma from 30 hospitals/pulmonary clinics in Hokkaido, Japan. The least square means and standard error were calculated for T-helper 2 (Th2) biomarkers and pulmonary function test across CC16 tertiles at baseline. We did the same for asthma exacerbation and annual decline in FEV(1) with 3 and 5 years' follow-up, respectively. RESULTS: We found that serum CC16 was inversely associated with sputum eosinophils and blood periostin in a dose-response manner. Baseline CC16 and FEV(1)/forced vital capacity ratio were positively associated in adjusted models (p for trend = 0.008). Patients with the lowest tertile of serum CC16 levels at baseline had a -14.3 mL decline in FEV(1) than those with the highest tertile over 5 years of follow-up (p for trend = 0.031, fully adjusted model). We did not find any association of CC16 with exacerbation risk. CONCLUSION: Patients with severe asthma with lower circulatory CC16 had enhanced eosinophilic inflammation with rapid FEV(1) decline over time.
Date:	2023-01
Relation:	Respiratory Medicine. 2023 Jan;206:Article number 107089.
Link to:	http://dx.doi.org/10.1016/j.rmed.2022.107089
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0954-6111&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000964067700001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85144799220
Appears in Collections:	[Shau-Ku Huang] Periodical Articles

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