國家衛生研究院 NHRI:Item 3990099045/14691
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14691


    Title: The effect of polysaccharides on preventing proteins and cholesterol from being adsorbed on the surface of orthokeratology lenses
    Authors: Wu, TY;Yeh, LK;Su, CY;Huang, PH;Lai, CC;Fang, HW
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: The adsorption of tear film compositions such as proteins and lipids on the orthokeratology lenses often lead to infection or corneal damage. In order to investigate whether polysaccharides could prevent tear compositions from being adsorbed on the lens, alginic acid and lambda-carrageenan were added into artificial tear solution. By measuring daily adsorption of cholesterol, lysozyme, and albumin, our results showed that polysaccharides could weakly prevent cholesterol adsorption. In addition, polysaccharides could also reduce albumin deposition over time. Although the effect of polysaccharides on lysozyme adsorption was distinct depending on the concentrations of polysaccharides, the overall results demonstrated that polysaccharides could decrease protein deposition over time. Our results provided an in vitro evidence that polysaccharides may be applied as coating materials on the lens or as the composition of artificial tear solutions or eyedrops, in order to prevent adsorption of tear film compositions that may lead to a reduced incidence of infection or corneal damage for orthokeratology lens wearers.
    Date: 2022-10-26
    Relation: Polymers. 2022 Oct 26;14(21):Article number 4542.
    Link to: http://dx.doi.org/10.3390/polym14214542
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2073-4360&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000882102700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85141865384
    Appears in Collections:[Others] Periodical Articles

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