國家衛生研究院 NHRI:Item 3990099045/14649
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14649


    Title: Gelation and the self-healing behavior of the chitosan-catechol hydrogel
    Authors: Lan, YT;Cheng, QP;Xu, JP;Lin, SH;Lin, JM;Hsu, SH
    Contributors: Institute of Cellular and Systems Medicine
    Abstract: Mussel-inspired adhesive hydrogels have been developed in biomedical fields due to their strong adhesive property, cohesive capability, biocompatibility, and hemostatic ability. Catecholfunctionalized chitosan is a potential polymer used to prepare adhesive hydrogels. However, the unique gelation mechanism and self-healing properties of catechol-grafted chitosan alone have not yet been explored. Herein, catechol-grafted chitosan (CC) was synthesized and further concentrated to obtain the self-healing CC hydrogels. The gelation mechanism of CC hydrogels may be attributed to the formation of hydrogen bonding, cationic-pi interactions, Michael addition, or Schiff base reactions during concentration phases. Rheological studies showed that the CC hydrogel owned self-healing properties in repeated damage-healing cycles. Coherent small-angle X-ray scattering (SAXS) analyses revealed the formation of a mesoscale structure (similar to 9 nm) as the solid content of the hydrogel increased. In situ SAXS combined with rheometry verified the strain-dependent behavior of the CC hydrogel. The CC hydrogel displayed the osmotic-responsive behavior and enhanced adhesive strength (0.38 N/cm(2)) after immersion in the physiological saline. The CC scaffold prepared by lyophilizing the CC hydrogel revealed a macroporous structure (similar to 200 mu m), a high swelling ratio (9656%), good compressibility, and durability. This work provides an insight into the design of using chitosan-catechol alone to produce hydrogels or scaffolds with tunable mechanical properties for further applications in biomedical fields.
    Date: 2022-10-30
    Relation: Polymers. 2022 Oct 30;14(21):Article number 4614.
    Link to: http://dx.doi.org/10.3390/polym14214614
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2073-4360&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000881479400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85141884701
    Appears in Collections:[Shan-Hui Hsu] Periodical Articles

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