國家衛生研究院 NHRI:Item 3990099045/14628
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    题名: Micro-CT analysis reveals the changes in bone mineral density in zebrafish craniofacial skeleton with age
    作者: Liao, WN;You, MS;Ulhaq, ZS;Li, JP;Jiang, YJ;Chen, JK;Tse, WKF
    贡献者: Institute of Biomedical Engineering and Nanomedicine;Institute of Molecular and Genomic Medicine
    摘要: Bone has multiple functions in animals, such as supporting the body for mobility. The zebrafish skeleton is composed of craniofacial and axial skeletons. It shares a physiological curvature and consists of a similar number of vertebrae as humans. Bone degeneration and malformations have been widely studied in zebrafish as human disease models. High-resolution imaging and different bone properties such as density and volume can be obtained using micro-computed tomography (micro-CT). This study aimed to understand the possible changes in the structure and bone mineral density (BMD) of the vertebrae and craniofacial skeleton with age (4, 12 and 24 months post fertilisation [mpf]) in zebrafish. Our data showed that the BMD in the vertebrae and specific craniofacial skeleton (mandibular arch, ceratohyal and ethmoid plate) of 12 and 24 mpf fish were higher than that of the 4 mpf fish. In addition, we found the age-dependent increase in BMD was not ubiquitously observed in facial bones, and such differences were not correlated with bone type. In summary, such additional information on the craniofacial skeleton could help in understanding bone development throughout the lifespan of zebrafish.
    日期: 2023-03
    關聯: Journal of Anatomy. 2023 Mar;242(3):544-551.
    Link to: http://dx.doi.org/10.1111/joa.13780
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0021-8782&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000869188400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85140087523
    显示于类别:[陳仁焜] 期刊論文
    [江運金] 期刊論文

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