國家衛生研究院 NHRI:Item 3990099045/14627

NHRI > Institute of Biomedical Engineering and Nanomedicine > Gin-Shin Chen > Periodical Articles > Item 3990099045/14627

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14627

Title:	Large-volume focused-ultrasound mild hyperthermia for improving blood-brain tumor barrier permeability application
Authors:	Chan, H;Chang, HY;Lin, WL;Chen, GS
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Mild hyperthermia can locally enhance permeability of the blood-tumor barrier in brain tumors, improving delivery of antitumor nanodrugs. However, a clinical transcranial focused ultrasound (FUS) system does not provide this modality yet. The study aimed at the development of the transcranial FUS technique dedicated for large-volume mild hyperthermia in the brain. Acoustic pressure, multiple-foci, temperature and thermal dose induced by FUS were simulated in the brain through the skull. A 1-MHz, 114-element, spherical helmet transducer was fabricated to verify large-volume hyperthermia in the phantom. The simulated results showed that two foci were simultaneously formed at (2, 0, 0) and (-2, 0, 0) and at (0, 2, 0) and (0, -2, 0), using the phases of focusing pattern 1 and the phases of focusing pattern 2, respectively. Switching two focusing patterns at 5 Hz produced a hyperthermic zone with an ellipsoid of 7 mm × 6 mm × 11 mm in the brain and the temperature was 41-45 °C in the ellipsoid as the maximum intensity was 150 W/cm(2) and sonication time was 3 min. The phased array driven by switching two mode phases generated a 41 °C-contour region of 10 ± 1 mm × 8 ± 2 mm × 13 ± 2 mm in the phantom after 3-min sonication. Therefore, we have demonstrated our developed FUS technique for large-volume mild hyperthermia.
Date:	2022-09-22
Relation:	Pharmaceutics. 2022 Sep 22;14(10):Article number 2012.
Link to:	http://dx.doi.org/10.3390/pharmaceutics14102012
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1999-4923&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000873557800001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85140840514
Appears in Collections:	[Gin-Shin Chen] Periodical Articles

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